CD44 Expression in Papillary Thyroid Carcinoma and its Correlation with Prognostic Factors
Background and purpose: Identifying the prognostic factors of malignancies is of particular importance in therapeutic decisions and identification of high-risk patients. Since the papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, we aimed to investigate the expression and prog...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2023-08-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-17772-en.pdf |
| _version_ | 1827698644908769280 |
|---|---|
| author | Fatemeh Baghertash Mohammadreza Jalali Nadoushan |
| author_facet | Fatemeh Baghertash Mohammadreza Jalali Nadoushan |
| author_sort | Fatemeh Baghertash |
| collection | DOAJ |
| description | Background and purpose: Identifying the prognostic factors of malignancies is of particular importance in therapeutic decisions and identification of high-risk patients. Since the papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, we aimed to investigate the expression and prognostic role of CD44 in patients with PTC.
Materials and methods: This cross-sectional study was performed in patients with PTC who underwent thyroidectomy in Tehran Mostafa Khomeini Hospital, 2015-2019. Demographic information, and macroscopic and microscopic characteristics of the tumor were extracted from pathology reports. CD44 expression was classified from negative to extremely positive. We assessed the correlation between CD44 expression and patients' demographic characteristics and clinicopathological characteristics of the tumor.
Results: Eighty PTC patients (58 females and 22 males) with a mean age of 40.85±4.59 years were studied. The frequency of lymph node and capsule invasion were 27.5% and 48.8%, respectively. The mean tumor size was 3.55±2.27 cm. All patients had more than 5% CD44 expression. Strongly positive and extremely positive cases of CD44 expression accounted for 43.8% and 21.3% of the cases, respectively. There was no significant difference in CD44 expression according to sex, age, and tumor size (P> 0.05). But, CD44 expression was found to be significantly associated with lymph node invasion (OR= 7.55) and especially capsule invasion (OR= 24.52).
Conclusion: Considering the relationship between CD44 expression and capsule and lymph node invasion in PTC, this biomarker can be used as a prognostic factor of more invasive disease in patients with PTC. |
| first_indexed | 2024-03-10T13:33:10Z |
| format | Article |
| id | doaj.art-a70c9975946b423394165d436ae1fe58 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-10T13:33:10Z |
| publishDate | 2023-08-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-a70c9975946b423394165d436ae1fe582023-11-21T07:44:02ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-08-01332233947CD44 Expression in Papillary Thyroid Carcinoma and its Correlation with Prognostic FactorsFatemeh Baghertash0Mohammadreza Jalali Nadoushan1 General Practitioner, Faculty of Medicine, Shahed University, Tehran, Iran Professor, Department of Pathology and Anatomical Sciences, Faculty of Medicine, Shahed University, Tehran, Iran Background and purpose: Identifying the prognostic factors of malignancies is of particular importance in therapeutic decisions and identification of high-risk patients. Since the papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, we aimed to investigate the expression and prognostic role of CD44 in patients with PTC. Materials and methods: This cross-sectional study was performed in patients with PTC who underwent thyroidectomy in Tehran Mostafa Khomeini Hospital, 2015-2019. Demographic information, and macroscopic and microscopic characteristics of the tumor were extracted from pathology reports. CD44 expression was classified from negative to extremely positive. We assessed the correlation between CD44 expression and patients' demographic characteristics and clinicopathological characteristics of the tumor. Results: Eighty PTC patients (58 females and 22 males) with a mean age of 40.85±4.59 years were studied. The frequency of lymph node and capsule invasion were 27.5% and 48.8%, respectively. The mean tumor size was 3.55±2.27 cm. All patients had more than 5% CD44 expression. Strongly positive and extremely positive cases of CD44 expression accounted for 43.8% and 21.3% of the cases, respectively. There was no significant difference in CD44 expression according to sex, age, and tumor size (P> 0.05). But, CD44 expression was found to be significantly associated with lymph node invasion (OR= 7.55) and especially capsule invasion (OR= 24.52). Conclusion: Considering the relationship between CD44 expression and capsule and lymph node invasion in PTC, this biomarker can be used as a prognostic factor of more invasive disease in patients with PTC.http://jmums.mazums.ac.ir/article-1-17772-en.pdfpapillary thyroid carcinomacd44prognosis |
| spellingShingle | Fatemeh Baghertash Mohammadreza Jalali Nadoushan CD44 Expression in Papillary Thyroid Carcinoma and its Correlation with Prognostic Factors Journal of Mazandaran University of Medical Sciences papillary thyroid carcinoma cd44 prognosis |
| title | CD44 Expression in Papillary Thyroid Carcinoma and its Correlation with Prognostic Factors |
| title_full | CD44 Expression in Papillary Thyroid Carcinoma and its Correlation with Prognostic Factors |
| title_fullStr | CD44 Expression in Papillary Thyroid Carcinoma and its Correlation with Prognostic Factors |
| title_full_unstemmed | CD44 Expression in Papillary Thyroid Carcinoma and its Correlation with Prognostic Factors |
| title_short | CD44 Expression in Papillary Thyroid Carcinoma and its Correlation with Prognostic Factors |
| title_sort | cd44 expression in papillary thyroid carcinoma and its correlation with prognostic factors |
| topic | papillary thyroid carcinoma cd44 prognosis |
| url | http://jmums.mazums.ac.ir/article-1-17772-en.pdf |
| work_keys_str_mv | AT fatemehbaghertash cd44expressioninpapillarythyroidcarcinomaanditscorrelationwithprognosticfactors AT mohammadrezajalalinadoushan cd44expressioninpapillarythyroidcarcinomaanditscorrelationwithprognosticfactors |