Networks Disrupted in Linguistic Variants of Frontotemporal Dementia
The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) and semantic variant (svPPA) of frontotemporal dementia (FTD) are neurodegenerative diseases. Previous works have shown alterations of fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor images (DTIs). T...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00903/full |
| _version_ | 1818608351759564800 |
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| author | Pablo Alexander Reyes Pablo Alexander Reyes Andrea del Pilar Rueda Felipe Uriza Diana L. Matallana |
| author_facet | Pablo Alexander Reyes Pablo Alexander Reyes Andrea del Pilar Rueda Felipe Uriza Diana L. Matallana |
| author_sort | Pablo Alexander Reyes |
| collection | DOAJ |
| description | The non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) and semantic variant (svPPA) of frontotemporal dementia (FTD) are neurodegenerative diseases. Previous works have shown alterations of fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor images (DTIs). This manuscript is aimed at using DTI images to build a global tractography and to identify atrophy patterns of white matter in each variant. Twenty patients with svPPA, 20 patients with nfvPPA, 26 patients with behavioral variant of FTD (bvFTD) and, 33 controls were included. An analysis based on the connectivity of structural networks showed changes in FA and MD in svPPA and nfvPPA with respect to bvFTD. Much damage in the internal networks of the left temporal lobe was found in svPPA patients; in contrast, patients with nfvPPA showed atrophy in networks from the basal ganglia to motor and premotor areas. Those findings support the dual stream model of speech and language. |
| first_indexed | 2024-12-16T14:41:16Z |
| format | Article |
| id | doaj.art-a70cf881ad0a46468ae281a9b2727ee2 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T14:41:16Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-a70cf881ad0a46468ae281a9b2727ee22022-12-21T22:27:55ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-08-011010.3389/fneur.2019.00903459101Networks Disrupted in Linguistic Variants of Frontotemporal DementiaPablo Alexander Reyes0Pablo Alexander Reyes1Andrea del Pilar Rueda2Felipe Uriza3Diana L. Matallana4Radiology Department, Hospital Universitario San Ignacio, Bogotá, ColombiaMedicine School, Aging Institute, Pontificia Universidad Javeriana, Bogotá, ColombiaBASPI, Faculty of Engineering, Pontificia Universidad Javeriana, Bogotá, ColombiaRadiology Department, Hospital Universitario San Ignacio, Bogotá, ColombiaMedicine School, Aging Institute, Pontificia Universidad Javeriana, Bogotá, ColombiaThe non-fluent/agrammatic variant of primary progressive aphasia (nfvPPA) and semantic variant (svPPA) of frontotemporal dementia (FTD) are neurodegenerative diseases. Previous works have shown alterations of fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor images (DTIs). This manuscript is aimed at using DTI images to build a global tractography and to identify atrophy patterns of white matter in each variant. Twenty patients with svPPA, 20 patients with nfvPPA, 26 patients with behavioral variant of FTD (bvFTD) and, 33 controls were included. An analysis based on the connectivity of structural networks showed changes in FA and MD in svPPA and nfvPPA with respect to bvFTD. Much damage in the internal networks of the left temporal lobe was found in svPPA patients; in contrast, patients with nfvPPA showed atrophy in networks from the basal ganglia to motor and premotor areas. Those findings support the dual stream model of speech and language.https://www.frontiersin.org/article/10.3389/fneur.2019.00903/fulldiffusion tensor imagingprimary progressive aphasiafrontotemporal dementiafractional anisotropywhite matterstructural connectivity |
| spellingShingle | Pablo Alexander Reyes Pablo Alexander Reyes Andrea del Pilar Rueda Felipe Uriza Diana L. Matallana Networks Disrupted in Linguistic Variants of Frontotemporal Dementia Frontiers in Neurology diffusion tensor imaging primary progressive aphasia frontotemporal dementia fractional anisotropy white matter structural connectivity |
| title | Networks Disrupted in Linguistic Variants of Frontotemporal Dementia |
| title_full | Networks Disrupted in Linguistic Variants of Frontotemporal Dementia |
| title_fullStr | Networks Disrupted in Linguistic Variants of Frontotemporal Dementia |
| title_full_unstemmed | Networks Disrupted in Linguistic Variants of Frontotemporal Dementia |
| title_short | Networks Disrupted in Linguistic Variants of Frontotemporal Dementia |
| title_sort | networks disrupted in linguistic variants of frontotemporal dementia |
| topic | diffusion tensor imaging primary progressive aphasia frontotemporal dementia fractional anisotropy white matter structural connectivity |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00903/full |
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