PTP1B Inhibition Causes Rac1 Activation by Enhancing Receptor Tyrosine Kinase Signaling

PTP1B Inhibition Causes Rac1 Activation by Enhancing Receptor Tyrosine Kinase Signaling

Background/Aims: The present study investigated the signaling pathway underlying Rac1 activation induced by the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA). Methods: Activity of protein tyrosine phosphatase 1B (PTP1B) was assayed under cell-free con...

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Bibliographic Details
Main Authors: Ayako Tsuchiya, Takeshi Kanno, Hisao Nagaya, Tadashi Shimizu, Akito Tanaka, Tomoyuki Nishizaki
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Protein tyrosine phosphatase 1B
Phosphatidylinositol 3 kinase
3-Phosphoinositide-dependent protein kinase-1
Akt
Rac1
Online Access:http://www.karger.com/Article/FullText/358679

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http://www.karger.com/Article/FullText/358679

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