RUNX1-Regulated Pathways and Biomarkers in Acute Myeloid Leukaemia
Runt-related transcription factor 1 gene (<i>RUNX1</i>), also known as acute myeloid leukaemia 1 protein (AML1), plays a crucial role in the pathogenesis of AML. RUNX1/AML1 is one of the most frequently mutated leukaemias associated with a poor prognosis in AML. Researchers and clinician...
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MDPI AG
2023-03-01
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| Series: | Medical Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9992/20/1/2 |
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| author | Deepesh Kumar Verma Hrishika Singh Chauhan Akhileshwar Namani |
| author_facet | Deepesh Kumar Verma Hrishika Singh Chauhan Akhileshwar Namani |
| author_sort | Deepesh Kumar Verma |
| collection | DOAJ |
| description | Runt-related transcription factor 1 gene (<i>RUNX1</i>), also known as acute myeloid leukaemia 1 protein (AML1), plays a crucial role in the pathogenesis of AML. RUNX1/AML1 is one of the most frequently mutated leukaemias associated with a poor prognosis in AML. Researchers and clinicians can develop personalized medicines and improve diagnosis by identifying the biomarkers associated with mutations. In the current study, we used the genome and transcriptome data from The Cancer Genome Atlas-Acute Myeloid Leukemia (TCGA-AML) cohort. We analysed <i>RUNX1</i> mutant AML patients compared to non-mutant patients using an integrated multi-omics, multi-database analysis of exome, and transcriptomics data. Finally, we identified the gene signature associated with <i>RUNX1</i> mutations, including prognostic genes that significantly influenced the overexpression of <i>RUNX1</i> mutation-associated genes in AML patients. Our results can help to diagnose AML patients with <i>RUNX1</i> mutations at an early stage. |
| first_indexed | 2024-03-11T02:06:30Z |
| format | Article |
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| issn | 2673-9992 |
| language | English |
| last_indexed | 2024-03-11T02:06:30Z |
| publishDate | 2023-03-01 |
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| record_format | Article |
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| spelling | doaj.art-a710dc492c4b40adb1ce2db56a0b051e2023-11-18T11:52:38ZengMDPI AGMedical Sciences Forum2673-99922023-03-01201210.3390/IECC2023-14279RUNX1-Regulated Pathways and Biomarkers in Acute Myeloid LeukaemiaDeepesh Kumar Verma0Hrishika Singh Chauhan1Akhileshwar Namani2Department of Biotechnology, GITAM (Gandhi Institute of Technology and Management) School of Sciences, GITAM (Deemed to be University), Visakhapatnam 530045, IndiaDepartment of Biotechnology, GITAM (Gandhi Institute of Technology and Management) School of Sciences, GITAM (Deemed to be University), Visakhapatnam 530045, IndiaDepartment of Biotechnology, GITAM (Gandhi Institute of Technology and Management) School of Sciences, GITAM (Deemed to be University), Visakhapatnam 530045, IndiaRunt-related transcription factor 1 gene (<i>RUNX1</i>), also known as acute myeloid leukaemia 1 protein (AML1), plays a crucial role in the pathogenesis of AML. RUNX1/AML1 is one of the most frequently mutated leukaemias associated with a poor prognosis in AML. Researchers and clinicians can develop personalized medicines and improve diagnosis by identifying the biomarkers associated with mutations. In the current study, we used the genome and transcriptome data from The Cancer Genome Atlas-Acute Myeloid Leukemia (TCGA-AML) cohort. We analysed <i>RUNX1</i> mutant AML patients compared to non-mutant patients using an integrated multi-omics, multi-database analysis of exome, and transcriptomics data. Finally, we identified the gene signature associated with <i>RUNX1</i> mutations, including prognostic genes that significantly influenced the overexpression of <i>RUNX1</i> mutation-associated genes in AML patients. Our results can help to diagnose AML patients with <i>RUNX1</i> mutations at an early stage.https://www.mdpi.com/2673-9992/20/1/2RUNX1acute myeloid leukaemiabiomarkersmulti-omics |
| spellingShingle | Deepesh Kumar Verma Hrishika Singh Chauhan Akhileshwar Namani RUNX1-Regulated Pathways and Biomarkers in Acute Myeloid Leukaemia Medical Sciences Forum RUNX1 acute myeloid leukaemia biomarkers multi-omics |
| title | RUNX1-Regulated Pathways and Biomarkers in Acute Myeloid Leukaemia |
| title_full | RUNX1-Regulated Pathways and Biomarkers in Acute Myeloid Leukaemia |
| title_fullStr | RUNX1-Regulated Pathways and Biomarkers in Acute Myeloid Leukaemia |
| title_full_unstemmed | RUNX1-Regulated Pathways and Biomarkers in Acute Myeloid Leukaemia |
| title_short | RUNX1-Regulated Pathways and Biomarkers in Acute Myeloid Leukaemia |
| title_sort | runx1 regulated pathways and biomarkers in acute myeloid leukaemia |
| topic | RUNX1 acute myeloid leukaemia biomarkers multi-omics |
| url | https://www.mdpi.com/2673-9992/20/1/2 |
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