BP180/Collagen XVII: A Molecular View
BP180 is a type II collagenous transmembrane protein and is best known as the major autoantigen in the blistering skin disease bullous pemphigoid (BP). The BP180 trimer is a central component in type I hemidesmosomes (HD), which cause the adhesion between epidermal keratinocytes and the basal lamina...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/22/12233 |
| _version_ | 1797510009842565120 |
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| author | Jussi Tuusa Nina Kokkonen Kaisa Tasanen |
| author_facet | Jussi Tuusa Nina Kokkonen Kaisa Tasanen |
| author_sort | Jussi Tuusa |
| collection | DOAJ |
| description | BP180 is a type II collagenous transmembrane protein and is best known as the major autoantigen in the blistering skin disease bullous pemphigoid (BP). The BP180 trimer is a central component in type I hemidesmosomes (HD), which cause the adhesion between epidermal keratinocytes and the basal lamina, but BP180 is also expressed in several non-HD locations, where its functions are poorly characterized. The immunological roles of intact and proteolytically processed BP180, relevant in BP, have been subject to intensive research, but novel functions in cell proliferation, differentiation, and aging have also recently been described. To better understand the multiple physiological functions of BP180, the focus should return to the protein itself. Here, we comprehensively review the properties of the BP180 molecule, present new data on the biochemical features of its intracellular domain, and discuss their significance with regard to BP180 folding and protein–protein interactions. |
| first_indexed | 2024-03-10T05:26:47Z |
| format | Article |
| id | doaj.art-a712ee00d3df459ab190b6be5b095e4b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:26:47Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a712ee00d3df459ab190b6be5b095e4b2023-11-22T23:39:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221223310.3390/ijms222212233BP180/Collagen XVII: A Molecular ViewJussi Tuusa0Nina Kokkonen1Kaisa Tasanen2PEDEGO Research Unit, Department of Dermatology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 8000, FI-90014 Oulu, FinlandPEDEGO Research Unit, Department of Dermatology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 8000, FI-90014 Oulu, FinlandPEDEGO Research Unit, Department of Dermatology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 8000, FI-90014 Oulu, FinlandBP180 is a type II collagenous transmembrane protein and is best known as the major autoantigen in the blistering skin disease bullous pemphigoid (BP). The BP180 trimer is a central component in type I hemidesmosomes (HD), which cause the adhesion between epidermal keratinocytes and the basal lamina, but BP180 is also expressed in several non-HD locations, where its functions are poorly characterized. The immunological roles of intact and proteolytically processed BP180, relevant in BP, have been subject to intensive research, but novel functions in cell proliferation, differentiation, and aging have also recently been described. To better understand the multiple physiological functions of BP180, the focus should return to the protein itself. Here, we comprehensively review the properties of the BP180 molecule, present new data on the biochemical features of its intracellular domain, and discuss their significance with regard to BP180 folding and protein–protein interactions.https://www.mdpi.com/1422-0067/22/22/12233autoimmune diseasebullous pemphigoidhemidesmosomeintrinsically disorderedkeratinocyteprotein–protein interaction |
| spellingShingle | Jussi Tuusa Nina Kokkonen Kaisa Tasanen BP180/Collagen XVII: A Molecular View International Journal of Molecular Sciences autoimmune disease bullous pemphigoid hemidesmosome intrinsically disordered keratinocyte protein–protein interaction |
| title | BP180/Collagen XVII: A Molecular View |
| title_full | BP180/Collagen XVII: A Molecular View |
| title_fullStr | BP180/Collagen XVII: A Molecular View |
| title_full_unstemmed | BP180/Collagen XVII: A Molecular View |
| title_short | BP180/Collagen XVII: A Molecular View |
| title_sort | bp180 collagen xvii a molecular view |
| topic | autoimmune disease bullous pemphigoid hemidesmosome intrinsically disordered keratinocyte protein–protein interaction |
| url | https://www.mdpi.com/1422-0067/22/22/12233 |
| work_keys_str_mv | AT jussituusa bp180collagenxviiamolecularview AT ninakokkonen bp180collagenxviiamolecularview AT kaisatasanen bp180collagenxviiamolecularview |