Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines
A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological evaluation of the synthesized c...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2016-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2016/0352-51391500097P.pdf |
| Summary: | A series of sixteen novel substituted piperidines and
(2-methoxyphenyl)piperazines were synthesized, starting from the key
intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and
1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological
evaluation of the synthesized compounds was pointed out for seven compounds,
of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl)piperidin-4-yl]methyl}piperazine
had the highest affinity for the dopamine D2 receptor. For all seven
selected compounds docking analysis was performed in order to establish
their structure-to-activity relationship. [Projekat Ministarstva nauke
Republike Srbije, br. 172032] |
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| ISSN: | 0352-5139 1820-7421 |