Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines
A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological evaluation of the synthesized c...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2016-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2016/0352-51391500097P.pdf |
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| author | Penjišević Jelena Z. Šukalović Vladimir V. Andrić Deana B. Roglić Goran M. Novaković Irena T. Šoškić Vukić Kostić-Rajačić Slađana V. |
| author_facet | Penjišević Jelena Z. Šukalović Vladimir V. Andrić Deana B. Roglić Goran M. Novaković Irena T. Šoškić Vukić Kostić-Rajačić Slađana V. |
| author_sort | Penjišević Jelena Z. |
| collection | DOAJ |
| description | A series of sixteen novel substituted piperidines and
(2-methoxyphenyl)piperazines were synthesized, starting from the key
intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and
1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological
evaluation of the synthesized compounds was pointed out for seven compounds,
of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl)piperidin-4-yl]methyl}piperazine
had the highest affinity for the dopamine D2 receptor. For all seven
selected compounds docking analysis was performed in order to establish
their structure-to-activity relationship. [Projekat Ministarstva nauke
Republike Srbije, br. 172032] |
| first_indexed | 2024-12-17T00:35:13Z |
| format | Article |
| id | doaj.art-a7137916291b4b4397e62894eeef55e3 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-17T00:35:13Z |
| publishDate | 2016-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-a7137916291b4b4397e62894eeef55e32022-12-21T22:10:10ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212016-01-0181434735610.2298/JSC151021097P0352-51391500097PSynthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazinesPenjišević Jelena Z.0Šukalović Vladimir V.1Andrić Deana B.2Roglić Goran M.3Novaković Irena T.4Šoškić Vukić5Kostić-Rajačić Slađana V.6ICTM - Center of Chemistry, BelgradeICTM - Center of Chemistry, BelgradeFaculty of Chemistry, BelgradeFaculty of Chemistry, BelgradeICTM - Center of Chemistry, BelgradeORGENTEC Diagnostica Gmbh, Mainz, GermanyICTM - Center of Chemistry, BelgradeA series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological evaluation of the synthesized compounds was pointed out for seven compounds, of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl)piperidin-4-yl]methyl}piperazine had the highest affinity for the dopamine D2 receptor. For all seven selected compounds docking analysis was performed in order to establish their structure-to-activity relationship. [Projekat Ministarstva nauke Republike Srbije, br. 172032]http://www.doiserbia.nb.rs/img/doi/0352-5139/2016/0352-51391500097P.pdfdopamine D2 receptordocking analysisallostericorthosteric bind site |
| spellingShingle | Penjišević Jelena Z. Šukalović Vladimir V. Andrić Deana B. Roglić Goran M. Novaković Irena T. Šoškić Vukić Kostić-Rajačić Slađana V. Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines Journal of the Serbian Chemical Society dopamine D2 receptor docking analysis allosteric orthosteric bind site |
| title | Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines |
| title_full | Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines |
| title_fullStr | Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines |
| title_full_unstemmed | Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines |
| title_short | Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines |
| title_sort | synthesis biological evaluation and docking analysis of substituted piperidines and 2 methoxyphenyl piperazines |
| topic | dopamine D2 receptor docking analysis allosteric orthosteric bind site |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2016/0352-51391500097P.pdf |
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