Integrated Metabolomics and Transcriptomics Suggest the Global Metabolic Response to 2-Aminoacrylate Stress in <i>Salmonella enterica</i>

Integrated Metabolomics and Transcriptomics Suggest the Global Metabolic Response to 2-Aminoacrylate Stress in <i>Salmonella enterica</i>

In <i>Salmonella enterica</i>, 2-aminoacrylate (2AA) is a reactive enamine intermediate generated during a number of biochemical reactions. When the 2-iminobutanoate/2-iminopropanoate deaminase (RidA; EC: 3.5.99.10) is eliminated, 2AA accumulates and inhibits the activity of multiple pyr...

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Bibliographic Details
Main Authors:	Andrew J. Borchert, Jacquelyn M. Walejko, Adrien Le Guennec, Dustin C. Ernst, Arthur S. Edison, Diana M. Downs
Format:	Article
Language:	English
Published:	MDPI AG 2019-12-01
Series:	Metabolites
Subjects:	2-aminoacrylate stress rida pyridoxal 5′-phosphate metabolic networks metabolomics <sup>1</sup>h nmr
Online Access:	https://www.mdpi.com/2218-1989/10/1/12

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