Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damage
Human and animal diseases have always been reported to be treated by medicinal herbs owing to their constituents. Excess sodium metavanadate is a potential environmental toxin when consumed and could induce oxidative damage leading to various neurological disorders and Parkinsons-like diseases. This...
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| Format: | Article |
| Language: | English |
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AIMS Press
2023-06-01
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| Series: | AIMS Neuroscience |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/Neuroscience.2023015?viewType=HTML |
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| author | Adeshina O. Adekeye Adedamola A. Fafure Morayo M. Omodele Lawrence D. Adedayo Victor O. Ekundina Damilare A. Adekomi Ephraim Samuel Jen Thomas K. Adenowo |
| author_facet | Adeshina O. Adekeye Adedamola A. Fafure Morayo M. Omodele Lawrence D. Adedayo Victor O. Ekundina Damilare A. Adekomi Ephraim Samuel Jen Thomas K. Adenowo |
| author_sort | Adeshina O. Adekeye |
| collection | DOAJ |
| description | Human and animal diseases have always been reported to be treated by medicinal herbs owing to their constituents. Excess sodium metavanadate is a potential environmental toxin when consumed and could induce oxidative damage leading to various neurological disorders and Parkinsons-like diseases. This study is designed to investigate the impact of the flavonoid Glycoside Fraction of Ginkgo Biloba Extract (GBE) (at 30 mg/kg body weight) on vanadium-treated rats. Animals were divided randomly into four groups: Control (Ctrl, normal saline), Ginkgo Biloba (GIBI, 30mg/kg BWT), Vanadium (VANA, 10 mg/kg BWT) and Vanadium + Ginkgo biloba (VANA + GIBI). Markers of oxidative stress (Glutathione Peroxidase and Catalase) were assessed and found to be statistically increased with GIBI when compared with CTRL and treatment groups. Results from routine staining revealed that the control and GIBI group had a normal distribution of cells and a pronounced increase in cell count respectively compared to the VANA group. When compared to the VANA group, the NeuN photomicrographs revealed that the levels of GIBI were within the normal range (***p < 0.001; ** p < 001). The treatment with GIBI showed a better response by increasing the neuronal cells in the VANA+GIBI when compared with the VANA group. The NLRP3 Inflammasome photomicrographs denoted that there was a decrease in NLRP3-positive cells in the control and GIBI groups. The treatment group shows fewer cells compared to that of the VANA group. The treatment group shows fewer cells compared to that of the VANA group. The findings of the study confirmed that ginkgo biloba extract via its flavonoid glycoside fraction has favorable impacts in modulating vanadium-induced brain damage with the potential ability to lower antioxidant levels and reduce neuroinflammation. |
| first_indexed | 2024-03-13T00:06:02Z |
| format | Article |
| id | doaj.art-a715d1e983d8472d81e7f63fe58c0e7b |
| institution | Directory Open Access Journal |
| issn | 2373-7972 |
| language | English |
| last_indexed | 2024-03-13T00:06:02Z |
| publishDate | 2023-06-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Neuroscience |
| spelling | doaj.art-a715d1e983d8472d81e7f63fe58c0e7b2023-07-13T01:24:39ZengAIMS PressAIMS Neuroscience2373-79722023-06-0110217818910.3934/Neuroscience.2023015Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damageAdeshina O. Adekeye 0Adedamola A. Fafure1Morayo M. Omodele2Lawrence D. Adedayo3Victor O. Ekundina4Damilare A. Adekomi5Ephraim Samuel Jen6Thomas K. Adenowo 71. Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria1. Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria1. Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria2. Department of Physiology, College of Health Sciences, Bowen University, Iwo, Osun State, Nigeria3. Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria4. Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Nigeria1. Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria5. Department of Anatomy, Faculty of Basic and applied Sciences, Lead City University, Ibadan, Oyo State, NigeriaHuman and animal diseases have always been reported to be treated by medicinal herbs owing to their constituents. Excess sodium metavanadate is a potential environmental toxin when consumed and could induce oxidative damage leading to various neurological disorders and Parkinsons-like diseases. This study is designed to investigate the impact of the flavonoid Glycoside Fraction of Ginkgo Biloba Extract (GBE) (at 30 mg/kg body weight) on vanadium-treated rats. Animals were divided randomly into four groups: Control (Ctrl, normal saline), Ginkgo Biloba (GIBI, 30mg/kg BWT), Vanadium (VANA, 10 mg/kg BWT) and Vanadium + Ginkgo biloba (VANA + GIBI). Markers of oxidative stress (Glutathione Peroxidase and Catalase) were assessed and found to be statistically increased with GIBI when compared with CTRL and treatment groups. Results from routine staining revealed that the control and GIBI group had a normal distribution of cells and a pronounced increase in cell count respectively compared to the VANA group. When compared to the VANA group, the NeuN photomicrographs revealed that the levels of GIBI were within the normal range (***p < 0.001; ** p < 001). The treatment with GIBI showed a better response by increasing the neuronal cells in the VANA+GIBI when compared with the VANA group. The NLRP3 Inflammasome photomicrographs denoted that there was a decrease in NLRP3-positive cells in the control and GIBI groups. The treatment group shows fewer cells compared to that of the VANA group. The treatment group shows fewer cells compared to that of the VANA group. The findings of the study confirmed that ginkgo biloba extract via its flavonoid glycoside fraction has favorable impacts in modulating vanadium-induced brain damage with the potential ability to lower antioxidant levels and reduce neuroinflammation.https://www.aimspress.com/article/doi/10.3934/Neuroscience.2023015?viewType=HTMLginkgo biloba extractinflammasomevanadiumneunglutathione peroxidase |
| spellingShingle | Adeshina O. Adekeye Adedamola A. Fafure Morayo M. Omodele Lawrence D. Adedayo Victor O. Ekundina Damilare A. Adekomi Ephraim Samuel Jen Thomas K. Adenowo Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damage AIMS Neuroscience ginkgo biloba extract inflammasome vanadium neun glutathione peroxidase |
| title | Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damage |
| title_full | Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damage |
| title_fullStr | Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damage |
| title_full_unstemmed | Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damage |
| title_short | Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damage |
| title_sort | flavonoid glycoside fraction of ginkgo biloba extract modulates antioxidants imbalance in vanadium induced brain damage |
| topic | ginkgo biloba extract inflammasome vanadium neun glutathione peroxidase |
| url | https://www.aimspress.com/article/doi/10.3934/Neuroscience.2023015?viewType=HTML |
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