Fetal Hippocampal Connectivity Shows Dissociable Associations with Maternal Cortisol and Self-Reported Distress during Pregnancy
Maternal stress can shape long-term child neurodevelopment beginning in utero. One mechanism by which stress is transmitted from mothers to their offspring is via alterations in maternal cortisol, which can cross the placenta and bind to glucocorticoid receptor-rich regions in the fetal brain, such...
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MDPI AG
2022-06-01
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| Online Access: | https://www.mdpi.com/2075-1729/12/7/943 |
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| author | Cassandra L. Hendrix Harini Srinivasan Integra Feliciano Justin M. Carré Moriah E. Thomason |
| author_facet | Cassandra L. Hendrix Harini Srinivasan Integra Feliciano Justin M. Carré Moriah E. Thomason |
| author_sort | Cassandra L. Hendrix |
| collection | DOAJ |
| description | Maternal stress can shape long-term child neurodevelopment beginning in utero. One mechanism by which stress is transmitted from mothers to their offspring is via alterations in maternal cortisol, which can cross the placenta and bind to glucocorticoid receptor-rich regions in the fetal brain, such as the hippocampus. Although prior studies have demonstrated associations between maternal prenatal stress and cortisol levels with child brain development, we lack information about the extent to which these associations originate prior to birth and prior to confounding postnatal influences. Pregnant mothers (<i>n</i> = 77) completed questionnaires about current perceived stress, depressive symptoms, and anxiety symptoms, provided three to four salivary cortisol samples, and completed a fetal resting-state functional MRI scan during their second or third trimester of pregnancy (mean gestational age = 32.8 weeks). Voxelwise seed-based connectivity analyses revealed that higher prenatal self-reported distress and higher maternal cortisol levels corresponded to dissociable differences in fetal hippocampal functional connectivity. Specifically, self-reported distress was correlated with increased positive functional coupling between the hippocampus and right posterior parietal association cortex, while higher maternal cortisol was associated with stronger positive hippocampal coupling with the dorsal anterior cingulate cortex and left medial prefrontal cortex. Moreover, the association between maternal distress, but not maternal cortisol, on fetal hippocampal connectivity was moderated by fetal sex. These results suggest that prenatal stress and peripheral cortisol levels may shape fetal hippocampal development through unique mechanisms. |
| first_indexed | 2024-03-09T10:16:36Z |
| format | Article |
| id | doaj.art-a71cffd8123f4de0a036c81d17446534 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T10:16:36Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
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| series | Life |
| spelling | doaj.art-a71cffd8123f4de0a036c81d174465342023-12-01T22:21:33ZengMDPI AGLife2075-17292022-06-0112794310.3390/life12070943Fetal Hippocampal Connectivity Shows Dissociable Associations with Maternal Cortisol and Self-Reported Distress during PregnancyCassandra L. Hendrix0Harini Srinivasan1Integra Feliciano2Justin M. Carré3Moriah E. Thomason4Department of Child and Adolescent Psychiatry, New York University Langone Health, New York, NY 10016, USADepartment of Child and Adolescent Psychiatry, New York University Langone Health, New York, NY 10016, USADepartment of Child and Adolescent Psychiatry, New York University Langone Health, New York, NY 10016, USADepartment of Psychology, Nipissing University, North Bay, ON P1B 8L7, CanadaDepartment of Child and Adolescent Psychiatry, New York University Langone Health, New York, NY 10016, USAMaternal stress can shape long-term child neurodevelopment beginning in utero. One mechanism by which stress is transmitted from mothers to their offspring is via alterations in maternal cortisol, which can cross the placenta and bind to glucocorticoid receptor-rich regions in the fetal brain, such as the hippocampus. Although prior studies have demonstrated associations between maternal prenatal stress and cortisol levels with child brain development, we lack information about the extent to which these associations originate prior to birth and prior to confounding postnatal influences. Pregnant mothers (<i>n</i> = 77) completed questionnaires about current perceived stress, depressive symptoms, and anxiety symptoms, provided three to four salivary cortisol samples, and completed a fetal resting-state functional MRI scan during their second or third trimester of pregnancy (mean gestational age = 32.8 weeks). Voxelwise seed-based connectivity analyses revealed that higher prenatal self-reported distress and higher maternal cortisol levels corresponded to dissociable differences in fetal hippocampal functional connectivity. Specifically, self-reported distress was correlated with increased positive functional coupling between the hippocampus and right posterior parietal association cortex, while higher maternal cortisol was associated with stronger positive hippocampal coupling with the dorsal anterior cingulate cortex and left medial prefrontal cortex. Moreover, the association between maternal distress, but not maternal cortisol, on fetal hippocampal connectivity was moderated by fetal sex. These results suggest that prenatal stress and peripheral cortisol levels may shape fetal hippocampal development through unique mechanisms.https://www.mdpi.com/2075-1729/12/7/943fetal programmingprenatal stressglucocorticoidsresting-state functional MRIdevelopmental neuroimagingsex differences |
| spellingShingle | Cassandra L. Hendrix Harini Srinivasan Integra Feliciano Justin M. Carré Moriah E. Thomason Fetal Hippocampal Connectivity Shows Dissociable Associations with Maternal Cortisol and Self-Reported Distress during Pregnancy Life fetal programming prenatal stress glucocorticoids resting-state functional MRI developmental neuroimaging sex differences |
| title | Fetal Hippocampal Connectivity Shows Dissociable Associations with Maternal Cortisol and Self-Reported Distress during Pregnancy |
| title_full | Fetal Hippocampal Connectivity Shows Dissociable Associations with Maternal Cortisol and Self-Reported Distress during Pregnancy |
| title_fullStr | Fetal Hippocampal Connectivity Shows Dissociable Associations with Maternal Cortisol and Self-Reported Distress during Pregnancy |
| title_full_unstemmed | Fetal Hippocampal Connectivity Shows Dissociable Associations with Maternal Cortisol and Self-Reported Distress during Pregnancy |
| title_short | Fetal Hippocampal Connectivity Shows Dissociable Associations with Maternal Cortisol and Self-Reported Distress during Pregnancy |
| title_sort | fetal hippocampal connectivity shows dissociable associations with maternal cortisol and self reported distress during pregnancy |
| topic | fetal programming prenatal stress glucocorticoids resting-state functional MRI developmental neuroimaging sex differences |
| url | https://www.mdpi.com/2075-1729/12/7/943 |
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