Placenta Accreta Spectrum Among Multiple Gestation: A Retrospective Analysis Based on a Chinese Population
BackgroundIt remained controversial whether women with multiple gestation are at higher risk of placenta accreta spectrum (PAS) disorders and large-scale studies are needed. This study aimed to assess whether PAS incidence is higher among women with multiple gestation than among singleton, as well a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.862785/full |
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| author | Zhirong Guo Zhirong Guo Xueyan Han Weiran Zheng Weiran Zheng Huixia Yang Huixia Yang Jingmei Ma Jingmei Ma |
| author_facet | Zhirong Guo Zhirong Guo Xueyan Han Weiran Zheng Weiran Zheng Huixia Yang Huixia Yang Jingmei Ma Jingmei Ma |
| author_sort | Zhirong Guo |
| collection | DOAJ |
| description | BackgroundIt remained controversial whether women with multiple gestation are at higher risk of placenta accreta spectrum (PAS) disorders and large-scale studies are needed. This study aimed to assess whether PAS incidence is higher among women with multiple gestation than among singleton, as well as to compare the characteristics and outcomes of PAS in multiple and singleton gestation.MethodsWomen who underwent cesarean section with live births at Peking University First Hospital from January 2015 to December 2020 were included. Demographic and clinical information was collected through chart review. Logistic regression models were used to analyze the associations between multiple gestation and PAS. The clinical characteristics and perioperative outcomes of PAS in multiple and singleton gestation were further compared.ResultsAmong the 14583 women included, 2.4% (352/14583) were diagnosed with PAS. PAS was slightly more prevalent among multiple gestations than among singletons (2.5% vs 2.4%, P=0.857). After adjusting for known risk factors and pregnancy complications, multiple gestation was associated with a higher risk of PAS (aOR=1.63, 95% CI 1.01-2.62). Among PAS patients, women who had multiple births had a significantly lower rate of previous cesarean deliveries (27.6% vs. 56.3%, P=0.003), placenta previa (17.2% vs. 56.3%, P<0.001) and invasive PAS (24.1% vs. 53.9, P=0.002) than singletons. There were no significant differences in perioperative outcomes between these two groups.ConclusionMultiple gestation could be independently associated with an elevated risk of PAS. The clinical characteristics of PAS in the multiple and singleton gestation groups differed significantly in cesarean delivery history and placenta previa. The results of this study may inform guidelines on the screening, early detection and timely intervention of PAS patients among women with multiple births. |
| first_indexed | 2024-12-12T10:52:00Z |
| format | Article |
| id | doaj.art-a71e49667d6e4ac788905b6590194b10 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T10:52:00Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a71e49667d6e4ac788905b6590194b102022-12-22T00:26:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-05-011310.3389/fendo.2022.862785862785Placenta Accreta Spectrum Among Multiple Gestation: A Retrospective Analysis Based on a Chinese PopulationZhirong Guo0Zhirong Guo1Xueyan Han2Weiran Zheng3Weiran Zheng4Huixia Yang5Huixia Yang6Jingmei Ma7Jingmei Ma8Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaBeijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Peking University First Hospital, Beijing, ChinaDepartment of Medical Statistics, Peking University First Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaBeijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Peking University First Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaBeijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Peking University First Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaBeijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Peking University First Hospital, Beijing, ChinaBackgroundIt remained controversial whether women with multiple gestation are at higher risk of placenta accreta spectrum (PAS) disorders and large-scale studies are needed. This study aimed to assess whether PAS incidence is higher among women with multiple gestation than among singleton, as well as to compare the characteristics and outcomes of PAS in multiple and singleton gestation.MethodsWomen who underwent cesarean section with live births at Peking University First Hospital from January 2015 to December 2020 were included. Demographic and clinical information was collected through chart review. Logistic regression models were used to analyze the associations between multiple gestation and PAS. The clinical characteristics and perioperative outcomes of PAS in multiple and singleton gestation were further compared.ResultsAmong the 14583 women included, 2.4% (352/14583) were diagnosed with PAS. PAS was slightly more prevalent among multiple gestations than among singletons (2.5% vs 2.4%, P=0.857). After adjusting for known risk factors and pregnancy complications, multiple gestation was associated with a higher risk of PAS (aOR=1.63, 95% CI 1.01-2.62). Among PAS patients, women who had multiple births had a significantly lower rate of previous cesarean deliveries (27.6% vs. 56.3%, P=0.003), placenta previa (17.2% vs. 56.3%, P<0.001) and invasive PAS (24.1% vs. 53.9, P=0.002) than singletons. There were no significant differences in perioperative outcomes between these two groups.ConclusionMultiple gestation could be independently associated with an elevated risk of PAS. The clinical characteristics of PAS in the multiple and singleton gestation groups differed significantly in cesarean delivery history and placenta previa. The results of this study may inform guidelines on the screening, early detection and timely intervention of PAS patients among women with multiple births.https://www.frontiersin.org/articles/10.3389/fendo.2022.862785/fullplacenta accreta spectrummultiple gestationclinical characteristicsperioperative outcomesassisted reproductive technology |
| spellingShingle | Zhirong Guo Zhirong Guo Xueyan Han Weiran Zheng Weiran Zheng Huixia Yang Huixia Yang Jingmei Ma Jingmei Ma Placenta Accreta Spectrum Among Multiple Gestation: A Retrospective Analysis Based on a Chinese Population Frontiers in Endocrinology placenta accreta spectrum multiple gestation clinical characteristics perioperative outcomes assisted reproductive technology |
| title | Placenta Accreta Spectrum Among Multiple Gestation: A Retrospective Analysis Based on a Chinese Population |
| title_full | Placenta Accreta Spectrum Among Multiple Gestation: A Retrospective Analysis Based on a Chinese Population |
| title_fullStr | Placenta Accreta Spectrum Among Multiple Gestation: A Retrospective Analysis Based on a Chinese Population |
| title_full_unstemmed | Placenta Accreta Spectrum Among Multiple Gestation: A Retrospective Analysis Based on a Chinese Population |
| title_short | Placenta Accreta Spectrum Among Multiple Gestation: A Retrospective Analysis Based on a Chinese Population |
| title_sort | placenta accreta spectrum among multiple gestation a retrospective analysis based on a chinese population |
| topic | placenta accreta spectrum multiple gestation clinical characteristics perioperative outcomes assisted reproductive technology |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.862785/full |
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