Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88

Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88

The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)-fed mice resulted in increased weight gain, impaired glucose homeostasis, elevated Dectin-1 expression in adipo...

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Main Authors: Angela Castoldi, Vinicius Andrade-Oliveira, Cristhiane Favero Aguiar, Mariane Tami Amano, Jennifer Lee, Marcelli Terumi Miyagi, Marcela Teatin Latância, Tarcio Teodoro Braga, Marina Burgos da Silva, Aline Ignácio, Joanna Darck Carola Correia Lima, Flavio V. Loures, José Antonio T. Albuquerque, Marina Barguil Macêdo, Rafael Ribeiro Almeida, Jonas W. Gaiarsa, Luis A. Luévano-Martínez, Thiago Belchior, Meire Ioshie Hiyane, Gordon D. Brown, Marcelo A. Mori, Christian Hoffmann, Marília Seelaender, Willian T. Festuccia, Pedro Manoel Moraes-Vieira, Niels Olsen Saraiva Câmara
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
MyD88
Dectin-1
obesity
insulin resistance
inflammation
macrophage
adipose tissue
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307167

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