Does non-invasive ventilation change metabolic markers in children with obstructive sleep apnoea? A systematic review and meta-analysis study protocol
Introduction Obstructive sleep apnoea (OSA) is not only common within paediatrics but is associated with critical childhood metabolic morbidity such as obesity, cardiovascular disease and glucose tolerance impairment. Increasing evidence suggests an association between childhood OSA and metabolic sy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/8/e039655.full |
| _version_ | 1818833179788705792 |
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| author | Meghan Sebastianski Christopher Gerdung Sara Rodriguez-Lopez Stefan Palkowski Diana Keto-Lambert Maria Luisa Castro Codesal |
| author_facet | Meghan Sebastianski Christopher Gerdung Sara Rodriguez-Lopez Stefan Palkowski Diana Keto-Lambert Maria Luisa Castro Codesal |
| author_sort | Meghan Sebastianski |
| collection | DOAJ |
| description | Introduction Obstructive sleep apnoea (OSA) is not only common within paediatrics but is associated with critical childhood metabolic morbidity such as obesity, cardiovascular disease and glucose tolerance impairment. Increasing evidence suggests an association between childhood OSA and metabolic syndrome such as markers of cardiovascular disease, systemic hypertension, glucose intoleranceand increased lipid profile. Recent studies have targeted changes in metabolic markers in children using non-invasive ventilation (NIV) but no systematic reviews are available to summarise this emerging evidence. The purpose of this systematic review is to provide systematic synthesis of the evidence on the effect of NIV use on metabolic markers in children with OSA.Methods and analysis A systematic search of electronic databases and grey literature will include paediatric interventional studies (random controlled trials, cohort studies) with and without a comparison group. Two reviewers will independently undertake the two step process of title/abstract and full-text screening. Data will be extracted and assessed, with aggregate data being reported. When the data allow, meta-analysis will be performed.Ethics and dissemination There are no ethical concerns with this systematic review, as data have previously been published. This review will inform clinicians taking care of children with OSA and obesity/metabolic syndrome about the potential effects of NIV therapies on metabolic markers and has the potential to change the approach to childhood OSA and obesity. Results of this systematic review will be submitted for dissemination in abstract and manuscript form. |
| first_indexed | 2024-12-19T02:14:49Z |
| format | Article |
| id | doaj.art-a720fcbfc9fd49b9995bfffcbe64a19a |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-12-19T02:14:49Z |
| publishDate | 2020-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-a720fcbfc9fd49b9995bfffcbe64a19a2022-12-21T20:40:27ZengBMJ Publishing GroupBMJ Open2044-60552020-08-0110810.1136/bmjopen-2020-039655Does non-invasive ventilation change metabolic markers in children with obstructive sleep apnoea? A systematic review and meta-analysis study protocolMeghan Sebastianski0Christopher Gerdung1Sara Rodriguez-Lopez2Stefan Palkowski3Diana Keto-Lambert4Maria Luisa Castro Codesal52 Alberta Strategy for Patient Oriented Research (SPOR) SUPPORT Unit Knowledge Translation Platform, University of Alberta, Edmonton, Alberta, Canada Pediatrics, University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, CanadaNephrology, Stollery Children's Hospital, Edmonton, Alberta, CanadaPediatrics, University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, CanadaPediatrics, University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, CanadaPediatrics, University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, CanadaIntroduction Obstructive sleep apnoea (OSA) is not only common within paediatrics but is associated with critical childhood metabolic morbidity such as obesity, cardiovascular disease and glucose tolerance impairment. Increasing evidence suggests an association between childhood OSA and metabolic syndrome such as markers of cardiovascular disease, systemic hypertension, glucose intoleranceand increased lipid profile. Recent studies have targeted changes in metabolic markers in children using non-invasive ventilation (NIV) but no systematic reviews are available to summarise this emerging evidence. The purpose of this systematic review is to provide systematic synthesis of the evidence on the effect of NIV use on metabolic markers in children with OSA.Methods and analysis A systematic search of electronic databases and grey literature will include paediatric interventional studies (random controlled trials, cohort studies) with and without a comparison group. Two reviewers will independently undertake the two step process of title/abstract and full-text screening. Data will be extracted and assessed, with aggregate data being reported. When the data allow, meta-analysis will be performed.Ethics and dissemination There are no ethical concerns with this systematic review, as data have previously been published. This review will inform clinicians taking care of children with OSA and obesity/metabolic syndrome about the potential effects of NIV therapies on metabolic markers and has the potential to change the approach to childhood OSA and obesity. Results of this systematic review will be submitted for dissemination in abstract and manuscript form.https://bmjopen.bmj.com/content/10/8/e039655.full |
| spellingShingle | Meghan Sebastianski Christopher Gerdung Sara Rodriguez-Lopez Stefan Palkowski Diana Keto-Lambert Maria Luisa Castro Codesal Does non-invasive ventilation change metabolic markers in children with obstructive sleep apnoea? A systematic review and meta-analysis study protocol BMJ Open |
| title | Does non-invasive ventilation change metabolic markers in children with obstructive sleep apnoea? A systematic review and meta-analysis study protocol |
| title_full | Does non-invasive ventilation change metabolic markers in children with obstructive sleep apnoea? A systematic review and meta-analysis study protocol |
| title_fullStr | Does non-invasive ventilation change metabolic markers in children with obstructive sleep apnoea? A systematic review and meta-analysis study protocol |
| title_full_unstemmed | Does non-invasive ventilation change metabolic markers in children with obstructive sleep apnoea? A systematic review and meta-analysis study protocol |
| title_short | Does non-invasive ventilation change metabolic markers in children with obstructive sleep apnoea? A systematic review and meta-analysis study protocol |
| title_sort | does non invasive ventilation change metabolic markers in children with obstructive sleep apnoea a systematic review and meta analysis study protocol |
| url | https://bmjopen.bmj.com/content/10/8/e039655.full |
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