Disconnected pancreatic duct syndrome in patients with necrotizing pancreatitis
In a subset of patients with acute necrotizing pancreatitis, segmental necrosis affecting the main pancreatic duct may result in a discontinuity between the left-sided pancreas and the duodenum. Such an interruption in the setting of a viable upstream portion of the gland can give rise to the discon...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Surgery Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589845022000707 |
| _version_ | 1828055153817681920 |
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| author | Petr Vanek, MD Ondrej Urban, MD, PhD Guru Trikudanathan, MD Martin L. Freeman, MD |
| author_facet | Petr Vanek, MD Ondrej Urban, MD, PhD Guru Trikudanathan, MD Martin L. Freeman, MD |
| author_sort | Petr Vanek, MD |
| collection | DOAJ |
| description | In a subset of patients with acute necrotizing pancreatitis, segmental necrosis affecting the main pancreatic duct may result in a discontinuity between the left-sided pancreas and the duodenum. Such an interruption in the setting of a viable upstream portion of the gland can give rise to the disconnected pancreatic duct syndrome (DPDS). By maintaining its secretory function, the disconnected segment may lead to persistent external pancreatic fistulae, recurrent pancreatic fluid collections, and/or obstructive recurrent acute or chronic pancreatitis of the isolated parenchyma. There are currently no universally accepted guidelines for the diagnosis or treatment of DPDS, and because the condition is underrecognized, the diagnosis is often delayed. DPDS is associated with a prolonged disease course and poses a burden on patients' quality of life as well as high health care resource utilization. The aim of our review is to summarize current knowledge, discuss diagnostic approaches, outline management options, and raise awareness of this challenging complication of necrotizing pancreatitis. |
| first_indexed | 2024-04-10T20:34:08Z |
| format | Article |
| id | doaj.art-a7216c1d04f44b57be06fb45ca3abf10 |
| institution | Directory Open Access Journal |
| issn | 2589-8450 |
| language | English |
| last_indexed | 2024-04-10T20:34:08Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Surgery Open Science |
| spelling | doaj.art-a7216c1d04f44b57be06fb45ca3abf102023-01-25T04:16:09ZengElsevierSurgery Open Science2589-84502023-01-01111925Disconnected pancreatic duct syndrome in patients with necrotizing pancreatitisPetr Vanek, MD0Ondrej Urban, MD, PhD1Guru Trikudanathan, MD2Martin L. Freeman, MD32nd Department of Internal Medicine – Gastroenterology and Geriatrics, University Hospital Olomouc, Faculty of Medicine, Palacky University, Olomouc, Czech Republic2nd Department of Internal Medicine – Gastroenterology and Geriatrics, University Hospital Olomouc, Faculty of Medicine, Palacky University, Olomouc, Czech RepublicDivision of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, USADivision of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, USA; Corresponding author at: University of Minnesota, MMC 36, 420 Delaware St SE, Minneapolis, MN 55455, USA.In a subset of patients with acute necrotizing pancreatitis, segmental necrosis affecting the main pancreatic duct may result in a discontinuity between the left-sided pancreas and the duodenum. Such an interruption in the setting of a viable upstream portion of the gland can give rise to the disconnected pancreatic duct syndrome (DPDS). By maintaining its secretory function, the disconnected segment may lead to persistent external pancreatic fistulae, recurrent pancreatic fluid collections, and/or obstructive recurrent acute or chronic pancreatitis of the isolated parenchyma. There are currently no universally accepted guidelines for the diagnosis or treatment of DPDS, and because the condition is underrecognized, the diagnosis is often delayed. DPDS is associated with a prolonged disease course and poses a burden on patients' quality of life as well as high health care resource utilization. The aim of our review is to summarize current knowledge, discuss diagnostic approaches, outline management options, and raise awareness of this challenging complication of necrotizing pancreatitis.http://www.sciencedirect.com/science/article/pii/S2589845022000707Acute necrotizing pancreatitisPancreatic duct disruptionPancreatic duct disconnectionDisconnected pancreatic duct syndromeWalled-off necrosisPancreatic pseudocyst |
| spellingShingle | Petr Vanek, MD Ondrej Urban, MD, PhD Guru Trikudanathan, MD Martin L. Freeman, MD Disconnected pancreatic duct syndrome in patients with necrotizing pancreatitis Surgery Open Science Acute necrotizing pancreatitis Pancreatic duct disruption Pancreatic duct disconnection Disconnected pancreatic duct syndrome Walled-off necrosis Pancreatic pseudocyst |
| title | Disconnected pancreatic duct syndrome in patients with necrotizing pancreatitis |
| title_full | Disconnected pancreatic duct syndrome in patients with necrotizing pancreatitis |
| title_fullStr | Disconnected pancreatic duct syndrome in patients with necrotizing pancreatitis |
| title_full_unstemmed | Disconnected pancreatic duct syndrome in patients with necrotizing pancreatitis |
| title_short | Disconnected pancreatic duct syndrome in patients with necrotizing pancreatitis |
| title_sort | disconnected pancreatic duct syndrome in patients with necrotizing pancreatitis |
| topic | Acute necrotizing pancreatitis Pancreatic duct disruption Pancreatic duct disconnection Disconnected pancreatic duct syndrome Walled-off necrosis Pancreatic pseudocyst |
| url | http://www.sciencedirect.com/science/article/pii/S2589845022000707 |
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