Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic Retinopathy
Diabetic Retinopathy (DR) is a leading cause of preventable visual impairment in the working age population. Despite the increasing prevalence of DR, there remain gaps in our understanding of its pathophysiology. This is a prospective case-control study comparing the genetic profiles of patients wit...
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MDPI AG
2023-03-01
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| Series: | Vision |
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| Online Access: | https://www.mdpi.com/2411-5150/7/1/18 |
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| author | Elizabeth Pearce Sobha Sivaprasad Suzanne Broadgate Christine Kiire Susan M. Downes Stephanie Halford Victor Chong |
| author_facet | Elizabeth Pearce Sobha Sivaprasad Suzanne Broadgate Christine Kiire Susan M. Downes Stephanie Halford Victor Chong |
| author_sort | Elizabeth Pearce |
| collection | DOAJ |
| description | Diabetic Retinopathy (DR) is a leading cause of preventable visual impairment in the working age population. Despite the increasing prevalence of DR, there remain gaps in our understanding of its pathophysiology. This is a prospective case-control study comparing the genetic profiles of patients with no DR vs. non-proliferative DR (NPDR) focusing on intraretinal microvascular abnormalities (IRMA) and venous beading (VB) in Caucasians. A total of 596 participants were recruited to the study; 199 with moderate/severe NPDR and 397 with diabetes for at least 5 years without DR. Sixty-four patients were excluded due to technical issues. In total, 532 were analysed; 181 and 351 were in the NPDR group and no DR group, respectively. Those with severe IRMA and VB had distinctly different genetic profiles from each other and from the no DR group, which further supports the theory that these two features of DR might have different etiologies. This also suggests that IRMA and VB are independent risk factors for the development of PDR and may have different pathophysiologies. If these findings are confirmed in larger studies, this could pave the way for personalised treatment options for those more at risk of developing different features of NPDR. |
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| format | Article |
| id | doaj.art-a722c688f4c54904855b627f42b39d18 |
| institution | Directory Open Access Journal |
| issn | 2411-5150 |
| language | English |
| last_indexed | 2024-03-11T05:46:01Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vision |
| spelling | doaj.art-a722c688f4c54904855b627f42b39d182023-11-17T14:24:56ZengMDPI AGVision2411-51502023-03-01711810.3390/vision7010018Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic RetinopathyElizabeth Pearce0Sobha Sivaprasad1Suzanne Broadgate2Christine Kiire3Susan M. Downes4Stephanie Halford5Victor Chong6King’s College Hospital NHS Trust, London SE5 9RS, UKNIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, London EC1V 2PD, UKNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford OX3 9DU, UKNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford OX3 9DU, UKNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford OX3 9DU, UKNuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford OX3 9DU, UKUCL Institute of Ophthalmology, London EC1V 9EL, UKDiabetic Retinopathy (DR) is a leading cause of preventable visual impairment in the working age population. Despite the increasing prevalence of DR, there remain gaps in our understanding of its pathophysiology. This is a prospective case-control study comparing the genetic profiles of patients with no DR vs. non-proliferative DR (NPDR) focusing on intraretinal microvascular abnormalities (IRMA) and venous beading (VB) in Caucasians. A total of 596 participants were recruited to the study; 199 with moderate/severe NPDR and 397 with diabetes for at least 5 years without DR. Sixty-four patients were excluded due to technical issues. In total, 532 were analysed; 181 and 351 were in the NPDR group and no DR group, respectively. Those with severe IRMA and VB had distinctly different genetic profiles from each other and from the no DR group, which further supports the theory that these two features of DR might have different etiologies. This also suggests that IRMA and VB are independent risk factors for the development of PDR and may have different pathophysiologies. If these findings are confirmed in larger studies, this could pave the way for personalised treatment options for those more at risk of developing different features of NPDR.https://www.mdpi.com/2411-5150/7/1/18non-proliferative diabetic retinopathyintraretinal microvascular abnormalitiesvenous beadingsingle nucleotide polymorphisms |
| spellingShingle | Elizabeth Pearce Sobha Sivaprasad Suzanne Broadgate Christine Kiire Susan M. Downes Stephanie Halford Victor Chong Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic Retinopathy Vision non-proliferative diabetic retinopathy intraretinal microvascular abnormalities venous beading single nucleotide polymorphisms |
| title | Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic Retinopathy |
| title_full | Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic Retinopathy |
| title_fullStr | Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic Retinopathy |
| title_full_unstemmed | Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic Retinopathy |
| title_short | Intraretinal Microvascular Abnormalities and Venous Beading Have Different Genetic Profiles in Caucasian Patients with Non-Proliferative Diabetic Retinopathy |
| title_sort | intraretinal microvascular abnormalities and venous beading have different genetic profiles in caucasian patients with non proliferative diabetic retinopathy |
| topic | non-proliferative diabetic retinopathy intraretinal microvascular abnormalities venous beading single nucleotide polymorphisms |
| url | https://www.mdpi.com/2411-5150/7/1/18 |
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