Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction

Targeting TLR4 with ApTOLL Improves Heart Function in Response to Coronary Ischemia Reperfusion in Pigs Undergoing Acute Myocardial Infarction

Toll-like receptor 4 (TLR4) contributes to the pathogenesis of coronary ischemia/reperfusion (IR). To test whether the new TLR4 antagonist, ApTOLL, may prevent coronary IR damage, we administered 0.078 mg/kg ApTOLL or Placebo in pigs subjected to IR, analyzing the levels of cardiac troponins, matrix...

Olles dieđut

Bibliográfalaš dieđut
Váldodahkkit: Rafael Ramirez-Carracedo, Laura Tesoro, Ignacio Hernandez, Javier Diez-Mata, David Piñeiro, Macarena Hernandez-Jimenez, Jose Luis Zamorano, Carlos Zaragoza
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: MDPI AG 2020-08-01
Ráidu:Biomolecules
Fáttát:
toll-like receptor 4
ApTOLL
acute myocardial infarction
cytokines
matrix metalloproteinases
Liŋkkat:https://www.mdpi.com/2218-273X/10/8/1167

Interneahtta

https://www.mdpi.com/2218-273X/10/8/1167

Geahča maid