A Comparison of Efficacy and Adverse Effects of Cetirizine and Desloratadine in 6-12-Year-Old Children with Allergic Rhinitis
Background: Antihistamines are the most common drugs used for treating allergic rhinitis. They, significantly, reduce nasal symptoms by blocking the action of a chemical cytokine called histamine. This study aimed to compare cetirizine and desloratadine's efficacy and adverse effects in childr...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-04-01
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| Series: | International Journal of Pediatrics |
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| Online Access: | https://ijp.mums.ac.ir/article_22215_9ffad6fbcefe25b6124281ab6d2d9845.pdf |
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| author | Mozhgan Moghtaderi Seyed Hesamedin Nabavizadeh Nasrin Moazzen mohammadreza Samadzadeh Mamaghani Sara Mostafavi Ali Mostafavi |
| author_facet | Mozhgan Moghtaderi Seyed Hesamedin Nabavizadeh Nasrin Moazzen mohammadreza Samadzadeh Mamaghani Sara Mostafavi Ali Mostafavi |
| author_sort | Mozhgan Moghtaderi |
| collection | DOAJ |
| description | Background: Antihistamines are the most common drugs used for treating allergic rhinitis. They, significantly, reduce nasal symptoms by blocking the action of a chemical cytokine called histamine. This study aimed to compare cetirizine and desloratadine's efficacy and adverse effects in children with allergic rhinitis.Method: This randomized single-blinded clinical trial was conducted on 400 children with allergic rhinitis, aged 6-12 between February and September 2022. The patients were randomized to receive cetirizine or desloratadine for four weeks. We recorded the symptoms and adverse effects at the baseline and four weeks after starting the intervention.Results: A total of 248 patients completed the study: 109 patients (47 female, 62 male) in the cetirizine group and 139 patients (53 female, 86 male) in the desloratadine group. The scores related to symptoms of allergic rhinitis before starting the drugs and after 4-week therapy were not significantly different between the two treatment groups (p= 0.1, p= 0.7, respectively). Cetirizine had more side effects than desloratadine in the treated patients (p = 0.02).Conclusion: This study showed that cetirizine and desloratadine improved symptoms of children with allergic rhinitis; however, there was no significant difference in the efficacy of these two drugs. Desloratadine caused fewer side effects in patients after 4 weeks of treatment. |
| first_indexed | 2024-03-12T05:35:45Z |
| format | Article |
| id | doaj.art-a7232e980e5645498f8a86a420462a2d |
| institution | Directory Open Access Journal |
| issn | 2345-5047 2345-5055 |
| language | English |
| last_indexed | 2024-03-12T05:35:45Z |
| publishDate | 2023-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj.art-a7232e980e5645498f8a86a420462a2d2023-09-03T06:29:28ZengMashhad University of Medical SciencesInternational Journal of Pediatrics2345-50472345-50552023-04-01114175831758910.22038/ijp.2023.70914.521222215A Comparison of Efficacy and Adverse Effects of Cetirizine and Desloratadine in 6-12-Year-Old Children with Allergic RhinitisMozhgan Moghtaderi0Seyed Hesamedin Nabavizadeh1Nasrin Moazzen2mohammadreza Samadzadeh Mamaghani3Sara Mostafavi4Ali Mostafavi5Neonatal Research Center, Shiraz University of Medical Science, Shiraz, IranDepartment of Pediatrics, Shiraz University of Medical Science, Shiraz, IranAllergy Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of pharmacology, Faculty of Veterinary Medicine, University of Tehran, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranUniversity of Arizona, Tucson, AZ 85721, USABackground: Antihistamines are the most common drugs used for treating allergic rhinitis. They, significantly, reduce nasal symptoms by blocking the action of a chemical cytokine called histamine. This study aimed to compare cetirizine and desloratadine's efficacy and adverse effects in children with allergic rhinitis.Method: This randomized single-blinded clinical trial was conducted on 400 children with allergic rhinitis, aged 6-12 between February and September 2022. The patients were randomized to receive cetirizine or desloratadine for four weeks. We recorded the symptoms and adverse effects at the baseline and four weeks after starting the intervention.Results: A total of 248 patients completed the study: 109 patients (47 female, 62 male) in the cetirizine group and 139 patients (53 female, 86 male) in the desloratadine group. The scores related to symptoms of allergic rhinitis before starting the drugs and after 4-week therapy were not significantly different between the two treatment groups (p= 0.1, p= 0.7, respectively). Cetirizine had more side effects than desloratadine in the treated patients (p = 0.02).Conclusion: This study showed that cetirizine and desloratadine improved symptoms of children with allergic rhinitis; however, there was no significant difference in the efficacy of these two drugs. Desloratadine caused fewer side effects in patients after 4 weeks of treatment.https://ijp.mums.ac.ir/article_22215_9ffad6fbcefe25b6124281ab6d2d9845.pdfcetirizine,,,،desloratadine,,,،allergic rhinitis,,,،histamine antagonists |
| spellingShingle | Mozhgan Moghtaderi Seyed Hesamedin Nabavizadeh Nasrin Moazzen mohammadreza Samadzadeh Mamaghani Sara Mostafavi Ali Mostafavi A Comparison of Efficacy and Adverse Effects of Cetirizine and Desloratadine in 6-12-Year-Old Children with Allergic Rhinitis International Journal of Pediatrics cetirizine,, ,،desloratadine,, ,،allergic rhinitis,, ,،histamine antagonists |
| title | A Comparison of Efficacy and Adverse Effects of Cetirizine and Desloratadine in 6-12-Year-Old Children with Allergic Rhinitis |
| title_full | A Comparison of Efficacy and Adverse Effects of Cetirizine and Desloratadine in 6-12-Year-Old Children with Allergic Rhinitis |
| title_fullStr | A Comparison of Efficacy and Adverse Effects of Cetirizine and Desloratadine in 6-12-Year-Old Children with Allergic Rhinitis |
| title_full_unstemmed | A Comparison of Efficacy and Adverse Effects of Cetirizine and Desloratadine in 6-12-Year-Old Children with Allergic Rhinitis |
| title_short | A Comparison of Efficacy and Adverse Effects of Cetirizine and Desloratadine in 6-12-Year-Old Children with Allergic Rhinitis |
| title_sort | comparison of efficacy and adverse effects of cetirizine and desloratadine in 6 12 year old children with allergic rhinitis |
| topic | cetirizine,, ,،desloratadine,, ,،allergic rhinitis,, ,،histamine antagonists |
| url | https://ijp.mums.ac.ir/article_22215_9ffad6fbcefe25b6124281ab6d2d9845.pdf |
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