A Case of Wolfram Syndrome

A Case of Wolfram Syndrome

Purpose: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. Case Report: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of -0.25+1.50@55 and -0....

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Bibliographic Details
Main Authors: Gholamali Naderian, Fereshteh Ashtari, Kia Nouri-Mahdavi, Valleh Sajjadi
Format: Article
Language:English
Published: Knowledge E 2010-01-01
Series:Journal of Ophthalmic & Vision Research
Subjects:
Diabetes Mellitus; Diabetes Insipidus; Deafness; Optic Atrophy
Online Access:http://www.jovr.org/article.asp?issn=2008-322X;year=2010;volume=5;issue=1;spage=53;epage=56;aulast=Naderian
Description
Summary:Purpose: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. Case Report: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of -0.25+1.50@55 and -0.25+1.50@131 in his right and left eyes, respectively. Bilateral optic atrophy was evident on fundus examination. The patient also had diabetes insipidus, neurosensory deafness, neurogenic bladder, polyuria and extra-residual voiding indicating atony of the urinary tract, combined with delayed sexual maturity. Conclusion: One should consider Wolfram syndrome in patients with juvenile onset diabetes mellitus and hearing loss. Ophthalmological examination may disclose optic atrophy; urologic examinations are vital in such patients.
ISSN:2008-322X

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