A Case of Wolfram Syndrome
Purpose: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. Case Report: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of -0.25+1.50@55 and -0....
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| Format: | Article |
| Language: | English |
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Knowledge E
2010-01-01
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| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | http://www.jovr.org/article.asp?issn=2008-322X;year=2010;volume=5;issue=1;spage=53;epage=56;aulast=Naderian |
| _version_ | 1811192818500108288 |
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| author | Gholamali Naderian Fereshteh Ashtari Kia Nouri-Mahdavi Valleh Sajjadi |
| author_facet | Gholamali Naderian Fereshteh Ashtari Kia Nouri-Mahdavi Valleh Sajjadi |
| author_sort | Gholamali Naderian |
| collection | DOAJ |
| description | Purpose: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy.
Case Report: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of -0.25+1.50@55 and -0.25+1.50@131 in his right and left eyes, respectively. Bilateral optic atrophy was evident on fundus examination. The patient also had diabetes insipidus, neurosensory deafness, neurogenic bladder, polyuria and extra-residual voiding indicating atony of the urinary tract, combined with delayed sexual maturity.
Conclusion: One should consider Wolfram syndrome in patients with juvenile onset diabetes mellitus and hearing loss. Ophthalmological examination may disclose optic atrophy; urologic examinations are vital in such patients. |
| first_indexed | 2024-04-11T23:58:47Z |
| format | Article |
| id | doaj.art-a7240fc947ea4fae93ae8f4f7c55dcd5 |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-11T23:58:47Z |
| publishDate | 2010-01-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-a7240fc947ea4fae93ae8f4f7c55dcd52022-12-22T03:56:17ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2010-01-01515356A Case of Wolfram SyndromeGholamali NaderianFereshteh AshtariKia Nouri-MahdaviValleh SajjadiPurpose: To report a case of Wolfram syndrome characterized by early onset diabetes mellitus and progressive optic atrophy. Case Report: A 20-year-old male patient with diabetes mellitus type I presented with best corrected visual acuity of 1/10 in both eyes with correction of -0.25+1.50@55 and -0.25+1.50@131 in his right and left eyes, respectively. Bilateral optic atrophy was evident on fundus examination. The patient also had diabetes insipidus, neurosensory deafness, neurogenic bladder, polyuria and extra-residual voiding indicating atony of the urinary tract, combined with delayed sexual maturity. Conclusion: One should consider Wolfram syndrome in patients with juvenile onset diabetes mellitus and hearing loss. Ophthalmological examination may disclose optic atrophy; urologic examinations are vital in such patients.http://www.jovr.org/article.asp?issn=2008-322X;year=2010;volume=5;issue=1;spage=53;epage=56;aulast=NaderianDiabetes Mellitus; Diabetes Insipidus; Deafness; Optic Atrophy |
| spellingShingle | Gholamali Naderian Fereshteh Ashtari Kia Nouri-Mahdavi Valleh Sajjadi A Case of Wolfram Syndrome Journal of Ophthalmic & Vision Research Diabetes Mellitus; Diabetes Insipidus; Deafness; Optic Atrophy |
| title | A Case of Wolfram Syndrome |
| title_full | A Case of Wolfram Syndrome |
| title_fullStr | A Case of Wolfram Syndrome |
| title_full_unstemmed | A Case of Wolfram Syndrome |
| title_short | A Case of Wolfram Syndrome |
| title_sort | case of wolfram syndrome |
| topic | Diabetes Mellitus; Diabetes Insipidus; Deafness; Optic Atrophy |
| url | http://www.jovr.org/article.asp?issn=2008-322X;year=2010;volume=5;issue=1;spage=53;epage=56;aulast=Naderian |
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