A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas
SMARCA1is a mammalian imitation switch (ISWI) gene that encodes for SNF2L. SNF2L is involved in regulating cell transition from a committed progenitor state to a differentiated state. Although many papers have detailed the correlation between SMARCA1 and different cancers, no pan-cancer analysis has...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488775/?tool=EBI |
| _version_ | 1798001420507545600 |
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| author | Lei Dai Joseph Mugaanyi Tongyue Zhang Jingshu Tong Xingchen Cai Caide Lu Changjiang Lu |
| author_facet | Lei Dai Joseph Mugaanyi Tongyue Zhang Jingshu Tong Xingchen Cai Caide Lu Changjiang Lu |
| author_sort | Lei Dai |
| collection | DOAJ |
| description | SMARCA1is a mammalian imitation switch (ISWI) gene that encodes for SNF2L. SNF2L is involved in regulating cell transition from a committed progenitor state to a differentiated state. Although many papers have detailed the correlation between SMARCA1 and different cancers, no pan-cancer analysis has been conducted to date. We started by exploring the potential carcinogenic role of SMARCA1 across 33 carcinomas using the cancer genome atlas (TCGA) and the genotype-tissue expression (GTEx) databases. The expression of SMARCA1 was significantly elevated in some tumor types but not in others. There was a distinct relationship between SMARCA1 expression and patient prognosis. S116 phosphorylation levels were up-regulated in both lung adenocarcinoma and uterine corpus endometrial carcinoma. The expression level of SMARCA1 was positively correlated with cancer-associated fibroblasts infiltration in a number of tumors, such as colon adenocarcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma. It was also associated with CD8+ T-cell infiltration in head and neck squamous cell carcinoma and lung adenocarcinoma. Furthermore, SMARCA1 is involved in chromatin remodeling and protein processing-associated mechanisms. Our study presents an initial assessment and illustration of the carcinogenic role of SMARCA1 in different carcinomas. |
| first_indexed | 2024-04-11T11:36:59Z |
| format | Article |
| id | doaj.art-a7241e2b4ac14cc490de4f18e7a08666 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T11:36:59Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a7241e2b4ac14cc490de4f18e7a086662022-12-22T04:25:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomasLei DaiJoseph MugaanyiTongyue ZhangJingshu TongXingchen CaiCaide LuChangjiang LuSMARCA1is a mammalian imitation switch (ISWI) gene that encodes for SNF2L. SNF2L is involved in regulating cell transition from a committed progenitor state to a differentiated state. Although many papers have detailed the correlation between SMARCA1 and different cancers, no pan-cancer analysis has been conducted to date. We started by exploring the potential carcinogenic role of SMARCA1 across 33 carcinomas using the cancer genome atlas (TCGA) and the genotype-tissue expression (GTEx) databases. The expression of SMARCA1 was significantly elevated in some tumor types but not in others. There was a distinct relationship between SMARCA1 expression and patient prognosis. S116 phosphorylation levels were up-regulated in both lung adenocarcinoma and uterine corpus endometrial carcinoma. The expression level of SMARCA1 was positively correlated with cancer-associated fibroblasts infiltration in a number of tumors, such as colon adenocarcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma. It was also associated with CD8+ T-cell infiltration in head and neck squamous cell carcinoma and lung adenocarcinoma. Furthermore, SMARCA1 is involved in chromatin remodeling and protein processing-associated mechanisms. Our study presents an initial assessment and illustration of the carcinogenic role of SMARCA1 in different carcinomas.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488775/?tool=EBI |
| spellingShingle | Lei Dai Joseph Mugaanyi Tongyue Zhang Jingshu Tong Xingchen Cai Caide Lu Changjiang Lu A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas PLoS ONE |
| title | A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas |
| title_full | A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas |
| title_fullStr | A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas |
| title_full_unstemmed | A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas |
| title_short | A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas |
| title_sort | pan cancer bioinformatic analysis of the carcinogenic role of smarca1 in human carcinomas |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9488775/?tool=EBI |
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