Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal disease
Abstract Background There is increasing evidence that diagnostic salivary tests measuring inflammatory biomarkers are being developed to assess inflammatory status for early detection, prevention, and progression of periodontal disease. Therefore, the aim of the present study was to investigate and...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-023-02874-7 |
| _version_ | 1797853538051686400 |
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| author | Kyoko Ishii Venkata Suresh Venkataiah Takako Kajiwara Kouta Umezawa Shigeto Suzuki Masato Nakano Mayu Sawaguchi Yoshio Yahata Masahiro Saito |
| author_facet | Kyoko Ishii Venkata Suresh Venkataiah Takako Kajiwara Kouta Umezawa Shigeto Suzuki Masato Nakano Mayu Sawaguchi Yoshio Yahata Masahiro Saito |
| author_sort | Kyoko Ishii |
| collection | DOAJ |
| description | Abstract Background There is increasing evidence that diagnostic salivary tests measuring inflammatory biomarkers are being developed to assess inflammatory status for early detection, prevention, and progression of periodontal disease. Therefore, the aim of the present study was to investigate and identify the salivary biomarker that can predict the inflammatory status of periodontal disease. Methods A total of 36 patients (28 women and 8 men) with an average age of 57 years were investigated. Unstimulated saliva was collected from the recruited subjects and analyzed using SillHa, a saliva-testing device that measures bacteria count, saliva buffer capacity, acidity, leukocyte esterase, protein, and ammonia. Periodontal parameters were then obtained by clinical examination and initial periodontal therapy was performed. Data obtained with SillHa were compared with clinical periodontal parameters at baseline, re-examination (three months from baseline), and final examination (six months from re-examination). Results Leukocyte esterase activity in saliva measured by SillHa; BOP and PCR measured by clinical examination showed a significant difference between baseline and final examination and between re-examination and final examination. Patients in the lower median group (group 1) had a significant difference in leukocyte esterase activity between baseline and final examination and re-examination and final examination. In addition, patients in Group 1 had significantly lower BOP between baseline and final examination. While patients in the higher median group (group 2) showed a modest decrease in leukocyte esterase activity, which was significant only between baseline and final examination, no significant changes were observed concerning BOP. Furthermore, the associated systemic disease was observed in 30% and 81.2% of group 1 and 2 patients, respectively. Conclusion The results suggest that leukocyte esterase activity in saliva measured by SillHa could serve as a reliable diagnostic marker for monitoring inflammatory status in periodontal disease. |
| first_indexed | 2024-04-09T19:52:14Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-09T19:52:14Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-a7245629bcb44ded85beaca56e73363c2023-04-03T05:42:47ZengBMCBMC Oral Health1472-68312023-03-0123111110.1186/s12903-023-02874-7Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal diseaseKyoko Ishii0Venkata Suresh Venkataiah1Takako Kajiwara2Kouta Umezawa3Shigeto Suzuki4Masato Nakano5Mayu Sawaguchi6Yoshio Yahata7Masahiro Saito8Division of Restorative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of DentistryDivision of Restorative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of DentistryDivision of Restorative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of DentistryDivision of Restorative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of DentistryDivision of Restorative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of DentistryDivision of Restorative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of DentistryDivision of Restorative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of DentistryDivision of Restorative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of DentistryDivision of Restorative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of DentistryAbstract Background There is increasing evidence that diagnostic salivary tests measuring inflammatory biomarkers are being developed to assess inflammatory status for early detection, prevention, and progression of periodontal disease. Therefore, the aim of the present study was to investigate and identify the salivary biomarker that can predict the inflammatory status of periodontal disease. Methods A total of 36 patients (28 women and 8 men) with an average age of 57 years were investigated. Unstimulated saliva was collected from the recruited subjects and analyzed using SillHa, a saliva-testing device that measures bacteria count, saliva buffer capacity, acidity, leukocyte esterase, protein, and ammonia. Periodontal parameters were then obtained by clinical examination and initial periodontal therapy was performed. Data obtained with SillHa were compared with clinical periodontal parameters at baseline, re-examination (three months from baseline), and final examination (six months from re-examination). Results Leukocyte esterase activity in saliva measured by SillHa; BOP and PCR measured by clinical examination showed a significant difference between baseline and final examination and between re-examination and final examination. Patients in the lower median group (group 1) had a significant difference in leukocyte esterase activity between baseline and final examination and re-examination and final examination. In addition, patients in Group 1 had significantly lower BOP between baseline and final examination. While patients in the higher median group (group 2) showed a modest decrease in leukocyte esterase activity, which was significant only between baseline and final examination, no significant changes were observed concerning BOP. Furthermore, the associated systemic disease was observed in 30% and 81.2% of group 1 and 2 patients, respectively. Conclusion The results suggest that leukocyte esterase activity in saliva measured by SillHa could serve as a reliable diagnostic marker for monitoring inflammatory status in periodontal disease.https://doi.org/10.1186/s12903-023-02874-7Saliva testPeriodontal diseaseLeukocyte esteraseDiagnostic markerOral hygiene |
| spellingShingle | Kyoko Ishii Venkata Suresh Venkataiah Takako Kajiwara Kouta Umezawa Shigeto Suzuki Masato Nakano Mayu Sawaguchi Yoshio Yahata Masahiro Saito Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal disease BMC Oral Health Saliva test Periodontal disease Leukocyte esterase Diagnostic marker Oral hygiene |
| title | Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal disease |
| title_full | Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal disease |
| title_fullStr | Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal disease |
| title_full_unstemmed | Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal disease |
| title_short | Salivary leukocyte esterase activity by SillHa is a risk indicator of periodontal disease |
| title_sort | salivary leukocyte esterase activity by sillha is a risk indicator of periodontal disease |
| topic | Saliva test Periodontal disease Leukocyte esterase Diagnostic marker Oral hygiene |
| url | https://doi.org/10.1186/s12903-023-02874-7 |
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