CTCF loss induces giant lamellar bodies in Purkinje cell dendrites

CTCF loss induces giant lamellar bodies in Purkinje cell dendrites

Abstract CCCTC-binding factor (CTCF) has a key role in higher-order chromatin architecture that is important for establishing and maintaining cell identity by controlling gene expression. In the mature cerebellum, CTCF is highly expressed in Purkinje cells (PCs) as compared with other cerebellar neu...

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Bibliographic Details
Main Authors: Teruyoshi Hirayama, Yuuki Kadooka, Etsuko Tarusawa, Sei Saitoh, Hisako Nakayama, Natsumi Hoshino, Soichiro Nakama, Takahiro Fukuishi, Yudai Kawanishi, Hiroki Umeshima, Koichi Tomita, Yumiko Yoshimura, Niels Galjart, Kouichi Hashimoto, Nobuhiko Ohno, Takeshi Yagi
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Acta Neuropathologica Communications
Subjects:
CCCTC-binding factor
Giant lamellar body
Purkinje cell
Neurodegeneration
Motor dysfunction
Online Access:https://doi.org/10.1186/s40478-022-01478-6

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