Unraveling the Role of Immune Checkpoints in Leishmaniasis
Leishmaniasis are Neglected Tropical Diseases affecting millions of people every year in at least 98 countries and is one of the major unsolved world health issues. Leishmania is a parasitic protozoa which are transmitted by infected sandflies and in the host they mainly infect macrophages. Immunity...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.620144/full |
| _version_ | 1818848251617476608 |
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| author | Rafael de Freitas e Silva Esther von Stebut |
| author_facet | Rafael de Freitas e Silva Esther von Stebut |
| author_sort | Rafael de Freitas e Silva |
| collection | DOAJ |
| description | Leishmaniasis are Neglected Tropical Diseases affecting millions of people every year in at least 98 countries and is one of the major unsolved world health issues. Leishmania is a parasitic protozoa which are transmitted by infected sandflies and in the host they mainly infect macrophages. Immunity elicited against those parasites is complex and immune checkpoints play a key role regulating its function. T cell receptors and their respective ligands, such as PD-1, CTLA-4, CD200, CD40, OX40, HVEM, LIGHT, 2B4 and TIM-3 have been characterized for their role in regulating adaptive immunity against different pathogens. However, the exact role those receptors perform during Leishmania infections remains to be better determined. This article addresses the key role immune checkpoints play during Leishmania infections, the limiting factors and translational implications. |
| first_indexed | 2024-12-19T06:14:22Z |
| format | Article |
| id | doaj.art-a72784a060eb409fb331a7a9cd008073 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T06:14:22Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a72784a060eb409fb331a7a9cd0080732022-12-21T20:32:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.620144620144Unraveling the Role of Immune Checkpoints in LeishmaniasisRafael de Freitas e Silva0Esther von Stebut1Department of Natural Sciences, University of Pernambuco, Garanhuns, BrazilDepartment of Dermatology, Medical Faculty, University of Cologne, Cologne, GermanyLeishmaniasis are Neglected Tropical Diseases affecting millions of people every year in at least 98 countries and is one of the major unsolved world health issues. Leishmania is a parasitic protozoa which are transmitted by infected sandflies and in the host they mainly infect macrophages. Immunity elicited against those parasites is complex and immune checkpoints play a key role regulating its function. T cell receptors and their respective ligands, such as PD-1, CTLA-4, CD200, CD40, OX40, HVEM, LIGHT, 2B4 and TIM-3 have been characterized for their role in regulating adaptive immunity against different pathogens. However, the exact role those receptors perform during Leishmania infections remains to be better determined. This article addresses the key role immune checkpoints play during Leishmania infections, the limiting factors and translational implications.https://www.frontiersin.org/articles/10.3389/fimmu.2021.620144/fullLeishmaniaLeishmaniasisImmune CheckpointsCo-inhibitory ReceptorsImmunotherapeutic |
| spellingShingle | Rafael de Freitas e Silva Esther von Stebut Unraveling the Role of Immune Checkpoints in Leishmaniasis Frontiers in Immunology Leishmania Leishmaniasis Immune Checkpoints Co-inhibitory Receptors Immunotherapeutic |
| title | Unraveling the Role of Immune Checkpoints in Leishmaniasis |
| title_full | Unraveling the Role of Immune Checkpoints in Leishmaniasis |
| title_fullStr | Unraveling the Role of Immune Checkpoints in Leishmaniasis |
| title_full_unstemmed | Unraveling the Role of Immune Checkpoints in Leishmaniasis |
| title_short | Unraveling the Role of Immune Checkpoints in Leishmaniasis |
| title_sort | unraveling the role of immune checkpoints in leishmaniasis |
| topic | Leishmania Leishmaniasis Immune Checkpoints Co-inhibitory Receptors Immunotherapeutic |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.620144/full |
| work_keys_str_mv | AT rafaeldefreitasesilva unravelingtheroleofimmunecheckpointsinleishmaniasis AT esthervonstebut unravelingtheroleofimmunecheckpointsinleishmaniasis |