PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds
Breast cancer is the most commonly diagnosed cancer in women. The high incidence of breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K–AKT pathway and its downstream targets influence various cellular processes. In recent years, mounting evidence has shown...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/1/93 |
| _version_ | 1827628207155707904 |
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| author | Yeqin Yuan Huizhi Long Ziwei Zhou Yuting Fu Binyuan Jiang |
| author_facet | Yeqin Yuan Huizhi Long Ziwei Zhou Yuting Fu Binyuan Jiang |
| author_sort | Yeqin Yuan |
| collection | DOAJ |
| description | Breast cancer is the most commonly diagnosed cancer in women. The high incidence of breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K–AKT pathway and its downstream targets influence various cellular processes. In recent years, mounting evidence has shown that natural products and synthetic drugs targeting PI3K–AKT signaling have the potential to treat breast cancer. In this review, we discuss the role of the PI3K–AKT signaling pathway in the occurrence and development of breast cancer and highlight PI3K–AKT-targeting natural products and drugs in clinical trials for the treatment of breast cancer. |
| first_indexed | 2024-03-09T13:27:31Z |
| format | Article |
| id | doaj.art-a728aba574d2417582cc7e97d396c3ba |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T13:27:31Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-a728aba574d2417582cc7e97d396c3ba2023-11-30T21:22:37ZengMDPI AGBiomolecules2218-273X2023-01-011319310.3390/biom13010093PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic CompoundsYeqin Yuan0Huizhi Long1Ziwei Zhou2Yuting Fu3Binyuan Jiang4Medical Research Center, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, ChinaSchool of Pharmacy, Hengyang Medical School, University of South China, Hengyang 421001, ChinaSchool of Pharmacy, Hengyang Medical School, University of South China, Hengyang 421001, ChinaMedical Research Center, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, ChinaMedical Research Center, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, ChinaBreast cancer is the most commonly diagnosed cancer in women. The high incidence of breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K–AKT pathway and its downstream targets influence various cellular processes. In recent years, mounting evidence has shown that natural products and synthetic drugs targeting PI3K–AKT signaling have the potential to treat breast cancer. In this review, we discuss the role of the PI3K–AKT signaling pathway in the occurrence and development of breast cancer and highlight PI3K–AKT-targeting natural products and drugs in clinical trials for the treatment of breast cancer.https://www.mdpi.com/2218-273X/13/1/93PI3K–AKT pathwaybreast cancernatural productsclinical trial drugs |
| spellingShingle | Yeqin Yuan Huizhi Long Ziwei Zhou Yuting Fu Binyuan Jiang PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds Biomolecules PI3K–AKT pathway breast cancer natural products clinical trial drugs |
| title | PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds |
| title_full | PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds |
| title_fullStr | PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds |
| title_full_unstemmed | PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds |
| title_short | PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds |
| title_sort | pi3k akt targeting breast cancer treatments natural products and synthetic compounds |
| topic | PI3K–AKT pathway breast cancer natural products clinical trial drugs |
| url | https://www.mdpi.com/2218-273X/13/1/93 |
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