The Interaction of Viruses with the Cellular Senescence Response
Cellular senescence is viewed as a mechanism to prevent malignant transformation, but when it is chronic, as occurs in age-related diseases, it may have adverse effects on cancer. Therefore, targeting senescent cells is a novel therapeutic strategy against senescence-associated diseases. In addition...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/9/12/455 |
| _version_ | 1797545256925790208 |
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| author | Rocío Seoane Santiago Vidal Yanis Hichem Bouzaher Ahmed El Motiam Carmen Rivas |
| author_facet | Rocío Seoane Santiago Vidal Yanis Hichem Bouzaher Ahmed El Motiam Carmen Rivas |
| author_sort | Rocío Seoane |
| collection | DOAJ |
| description | Cellular senescence is viewed as a mechanism to prevent malignant transformation, but when it is chronic, as occurs in age-related diseases, it may have adverse effects on cancer. Therefore, targeting senescent cells is a novel therapeutic strategy against senescence-associated diseases. In addition to its role in cancer protection, cellular senescence is also considered a mechanism to control virus replication. Both interferon treatment and some viral infections can trigger cellular senescence as a way to restrict virus replication. However, activation of the cellular senescence program is linked to the alteration of different pathways, which can be exploited by some viruses to improve their replication. It is, therefore, important to understand the potential impact of senolytic agents on viral propagation. Here we focus on the relationship between virus and cellular senescence and the reported effects of senolytic compounds on virus replication. |
| first_indexed | 2024-03-10T14:12:56Z |
| format | Article |
| id | doaj.art-a729e8dadbc24981acdef015cbf34bcb |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T14:12:56Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-a729e8dadbc24981acdef015cbf34bcb2023-11-21T00:03:20ZengMDPI AGBiology2079-77372020-12-0191245510.3390/biology9120455The Interaction of Viruses with the Cellular Senescence ResponseRocío Seoane0Santiago Vidal1Yanis Hichem Bouzaher2Ahmed El Motiam3Carmen Rivas4Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, 15706 Santiago de Compostela, SpainCentro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, 15706 Santiago de Compostela, SpainCentro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, 15706 Santiago de Compostela, SpainCentro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, 15706 Santiago de Compostela, SpainCentro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, 15706 Santiago de Compostela, SpainCellular senescence is viewed as a mechanism to prevent malignant transformation, but when it is chronic, as occurs in age-related diseases, it may have adverse effects on cancer. Therefore, targeting senescent cells is a novel therapeutic strategy against senescence-associated diseases. In addition to its role in cancer protection, cellular senescence is also considered a mechanism to control virus replication. Both interferon treatment and some viral infections can trigger cellular senescence as a way to restrict virus replication. However, activation of the cellular senescence program is linked to the alteration of different pathways, which can be exploited by some viruses to improve their replication. It is, therefore, important to understand the potential impact of senolytic agents on viral propagation. Here we focus on the relationship between virus and cellular senescence and the reported effects of senolytic compounds on virus replication.https://www.mdpi.com/2079-7737/9/12/455senescencesenolyticsvirosenolyticsvirus |
| spellingShingle | Rocío Seoane Santiago Vidal Yanis Hichem Bouzaher Ahmed El Motiam Carmen Rivas The Interaction of Viruses with the Cellular Senescence Response Biology senescence senolytics virosenolytics virus |
| title | The Interaction of Viruses with the Cellular Senescence Response |
| title_full | The Interaction of Viruses with the Cellular Senescence Response |
| title_fullStr | The Interaction of Viruses with the Cellular Senescence Response |
| title_full_unstemmed | The Interaction of Viruses with the Cellular Senescence Response |
| title_short | The Interaction of Viruses with the Cellular Senescence Response |
| title_sort | interaction of viruses with the cellular senescence response |
| topic | senescence senolytics virosenolytics virus |
| url | https://www.mdpi.com/2079-7737/9/12/455 |
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