Synthesis and Estimation of the Insecticide and Antibacterial Activities for Some New Amide Derivatives
In this work, new compounds of amide derivatives (C1-C3) were synthesized through the conversion reaction of p-chloroaniline to diazonium salt (B1), which reacts with aniline to form a new azo-compound (B3). Synthesized of p-alkoxybenzoic acid (A1-A3) and reacts with SOCl2 to form A4-A6 compounds th...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2023-12-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/81972 |
| _version_ | 1797336389289771008 |
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| author | Zinah Hussein Ali Dina Saleem Abbas Khudhair Abbas Baneen Salam Rasool Mustafa Sabri Cheyad |
| author_facet | Zinah Hussein Ali Dina Saleem Abbas Khudhair Abbas Baneen Salam Rasool Mustafa Sabri Cheyad |
| author_sort | Zinah Hussein Ali |
| collection | DOAJ |
| description | In this work, new compounds of amide derivatives (C1-C3) were synthesized through the conversion reaction of p-chloroaniline to diazonium salt (B1), which reacts with aniline to form a new azo-compound (B3). Synthesized of p-alkoxybenzoic acid (A1-A3) and reacts with SOCl2 to form A4-A6 compounds that react with B3 compound to form amide compounds (C1-C3). The synthesized derivatives were tested by docking analysis and characterized via FTIR, 1H-NMR spectra. In the docking study, the interaction diagram also displays many van der Waals interactions, which are used to estimate the synthetic compounds' activity as insecticides like anti-termites. Heptyl came in first on the binding score, followed by octyl and then nonyl. Due to the compounds' modified conformation in interacting with the enzyme's binding pocket, the length of the alkyl residue of the derivative adversely impacted their binding inhibition. The synthesized compounds (C1 and C3) give a good result as anti-E. coli and anti-Staphylococcus strains. |
| first_indexed | 2024-03-08T08:53:42Z |
| format | Article |
| id | doaj.art-a72acac62bf948a6ad5e67b112f4415f |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-03-08T08:53:42Z |
| publishDate | 2023-12-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-a72acac62bf948a6ad5e67b112f4415f2024-02-01T07:39:03ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782023-12-012361535154110.22146/ijc.8197234578Synthesis and Estimation of the Insecticide and Antibacterial Activities for Some New Amide DerivativesZinah Hussein Ali0Dina Saleem1Abbas Khudhair Abbas2Baneen Salam Rasool3Mustafa Sabri Cheyad4Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad 10052, IraqDepartment of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad 10052, IraqMuthanna Agriculture Directorate, Ministry of Agriculture, Al-Muthanna 66001, IraqCollege of Science, Al-Nahrain University, Baghdad 10072, IraqOil Products Distribution Company (OPDC), Ministry of Oil, Baghdad 10022, IraqIn this work, new compounds of amide derivatives (C1-C3) were synthesized through the conversion reaction of p-chloroaniline to diazonium salt (B1), which reacts with aniline to form a new azo-compound (B3). Synthesized of p-alkoxybenzoic acid (A1-A3) and reacts with SOCl2 to form A4-A6 compounds that react with B3 compound to form amide compounds (C1-C3). The synthesized derivatives were tested by docking analysis and characterized via FTIR, 1H-NMR spectra. In the docking study, the interaction diagram also displays many van der Waals interactions, which are used to estimate the synthetic compounds' activity as insecticides like anti-termites. Heptyl came in first on the binding score, followed by octyl and then nonyl. Due to the compounds' modified conformation in interacting with the enzyme's binding pocket, the length of the alkyl residue of the derivative adversely impacted their binding inhibition. The synthesized compounds (C1 and C3) give a good result as anti-E. coli and anti-Staphylococcus strains.https://jurnal.ugm.ac.id/ijc/article/view/81972amideazoinsecticidebacterial |
| spellingShingle | Zinah Hussein Ali Dina Saleem Abbas Khudhair Abbas Baneen Salam Rasool Mustafa Sabri Cheyad Synthesis and Estimation of the Insecticide and Antibacterial Activities for Some New Amide Derivatives Indonesian Journal of Chemistry amide azo insecticide bacterial |
| title | Synthesis and Estimation of the Insecticide and Antibacterial Activities for Some New Amide Derivatives |
| title_full | Synthesis and Estimation of the Insecticide and Antibacterial Activities for Some New Amide Derivatives |
| title_fullStr | Synthesis and Estimation of the Insecticide and Antibacterial Activities for Some New Amide Derivatives |
| title_full_unstemmed | Synthesis and Estimation of the Insecticide and Antibacterial Activities for Some New Amide Derivatives |
| title_short | Synthesis and Estimation of the Insecticide and Antibacterial Activities for Some New Amide Derivatives |
| title_sort | synthesis and estimation of the insecticide and antibacterial activities for some new amide derivatives |
| topic | amide azo insecticide bacterial |
| url | https://jurnal.ugm.ac.id/ijc/article/view/81972 |
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