Effect of Epicardial Adipose Tissue on In-stent Restenosis after Percutaneous Coronary Intervention: a Review
As a major treatment for coronary artery disease, percutaneous coronary intervention (PCI) effectively enhances the survival rate of patients. However, the post-PCI in-stent restenosis has become a new cardiovascular problem that is difficult to solve. Inflammation and endothelial dysfunction, as th...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2023-03-01
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| Series: | Zhongguo quanke yixue |
| Subjects: | |
| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220453.pdf |
| _version_ | 1797216849097654272 |
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| author | AN Jingjing, WANG Xiaojuan, DENG Aiyun |
| author_facet | AN Jingjing, WANG Xiaojuan, DENG Aiyun |
| author_sort | AN Jingjing, WANG Xiaojuan, DENG Aiyun |
| collection | DOAJ |
| description | As a major treatment for coronary artery disease, percutaneous coronary intervention (PCI) effectively enhances the survival rate of patients. However, the post-PCI in-stent restenosis has become a new cardiovascular problem that is difficult to solve. Inflammation and endothelial dysfunction, as the initiating inducing factors of in-stent restenosis, together with subsequently developed neointimal thickening and neoatherosclerosis based on which, promote the progression of in-stent restenosis. Inflammatory markers secreted by epicardial adipose tissue may directly influence the function of coronary vascular endothelial cells, smooth muscle cells and macrophages, disrupting the homeostasis of the coronary vessel wall, thereby being involved in the pathophysiological process of in-stent restenosis after coronary stenting. In addition, multiple clinical studies have shown that epicardial adipose tissue could partially predict in-stent restenosis in patients with coronary artery disease within 1 year after PCI. We reviewed the latest advances in the effect of epicardial adipose tissue on in-stent restenosis after PCI, and clinical prediction of post-PCI in-stent restenosis by epicardial fat, as well as treatment for post-PCI in-stent restenosis, providing a new idea for the prevention and treatment of post-PCI in-stent restenosis. |
| first_indexed | 2024-04-24T11:52:29Z |
| format | Article |
| id | doaj.art-a72ad874135a4bea886f54cec593c4b7 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:52:29Z |
| publishDate | 2023-03-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-a72ad874135a4bea886f54cec593c4b72024-04-09T07:29:01ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722023-03-0126091146115010.12114/j.issn.1007-9572.2022.0453Effect of Epicardial Adipose Tissue on In-stent Restenosis after Percutaneous Coronary Intervention: a ReviewAN Jingjing, WANG Xiaojuan, DENG Aiyun01. The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China;2. Department of Cardiology, the First Hospital of Lanzhou University, Lanzhou 730000, ChinaAs a major treatment for coronary artery disease, percutaneous coronary intervention (PCI) effectively enhances the survival rate of patients. However, the post-PCI in-stent restenosis has become a new cardiovascular problem that is difficult to solve. Inflammation and endothelial dysfunction, as the initiating inducing factors of in-stent restenosis, together with subsequently developed neointimal thickening and neoatherosclerosis based on which, promote the progression of in-stent restenosis. Inflammatory markers secreted by epicardial adipose tissue may directly influence the function of coronary vascular endothelial cells, smooth muscle cells and macrophages, disrupting the homeostasis of the coronary vessel wall, thereby being involved in the pathophysiological process of in-stent restenosis after coronary stenting. In addition, multiple clinical studies have shown that epicardial adipose tissue could partially predict in-stent restenosis in patients with coronary artery disease within 1 year after PCI. We reviewed the latest advances in the effect of epicardial adipose tissue on in-stent restenosis after PCI, and clinical prediction of post-PCI in-stent restenosis by epicardial fat, as well as treatment for post-PCI in-stent restenosis, providing a new idea for the prevention and treatment of post-PCI in-stent restenosis.https://www.chinagp.net/fileup/1007-9572/PDF/zx20220453.pdfpercutaneous coronary intervention|in-stent restenosis|drug-eluting stents|epicardial adipose tissue|coronary disease |
| spellingShingle | AN Jingjing, WANG Xiaojuan, DENG Aiyun Effect of Epicardial Adipose Tissue on In-stent Restenosis after Percutaneous Coronary Intervention: a Review Zhongguo quanke yixue percutaneous coronary intervention|in-stent restenosis|drug-eluting stents|epicardial adipose tissue|coronary disease |
| title | Effect of Epicardial Adipose Tissue on In-stent Restenosis after Percutaneous Coronary Intervention: a Review |
| title_full | Effect of Epicardial Adipose Tissue on In-stent Restenosis after Percutaneous Coronary Intervention: a Review |
| title_fullStr | Effect of Epicardial Adipose Tissue on In-stent Restenosis after Percutaneous Coronary Intervention: a Review |
| title_full_unstemmed | Effect of Epicardial Adipose Tissue on In-stent Restenosis after Percutaneous Coronary Intervention: a Review |
| title_short | Effect of Epicardial Adipose Tissue on In-stent Restenosis after Percutaneous Coronary Intervention: a Review |
| title_sort | effect of epicardial adipose tissue on in stent restenosis after percutaneous coronary intervention a review |
| topic | percutaneous coronary intervention|in-stent restenosis|drug-eluting stents|epicardial adipose tissue|coronary disease |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220453.pdf |
| work_keys_str_mv | AT anjingjingwangxiaojuandengaiyun effectofepicardialadiposetissueoninstentrestenosisafterpercutaneouscoronaryinterventionareview |