Structure–Function Relationships and Glaucoma Detection with Magnification Correction of OCT Angiography
Purpose: To investigate the effects of adjusting the ocular magnification during OCT-based angiography imaging on structure–function relationships and glaucoma detection. Design: Cross-sectional study. Participants: A total of 96 healthy control participants and 90 patients with open-angle glaucoma...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Ophthalmology Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666914522000094 |
| _version_ | 1818249314789490688 |
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| author | Kazunori Hirasawa, CO, PhD Jun Yamaguchi, CO Koichi Nagano, CO Junji Kanno, CO Masayuki Kasahara, MD, PhD Nobuyuki Shoji, MD, PhD |
| author_facet | Kazunori Hirasawa, CO, PhD Jun Yamaguchi, CO Koichi Nagano, CO Junji Kanno, CO Masayuki Kasahara, MD, PhD Nobuyuki Shoji, MD, PhD |
| author_sort | Kazunori Hirasawa, CO, PhD |
| collection | DOAJ |
| description | Purpose: To investigate the effects of adjusting the ocular magnification during OCT-based angiography imaging on structure–function relationships and glaucoma detection. Design: Cross-sectional study. Participants: A total of 96 healthy control participants and 90 patients with open-angle glaucoma were included. Methods: One eye of each patient in the control group and the patient group was evaluated. The layers comprising the macula vascular density (VD) and circumpapillary VD were derived from swept-source OCT angiography imaging. The mean sensitivity (MS) of the standard automated perimetry was measured using the Humphrey 24-2 test. Structure–function relationships were evaluated with simple and partial correlation coefficients. A receiver operating characteristic analysis was performed to evaluate the diagnostic accuracy for glaucoma using the area under the receiver operating characteristic curve (AUC). Ocular magnification was adjusted using Littmann’s formula modified by Bennett. Main Outcome Measures: The association between the axial length and VD, structure–function relationships, and glaucoma detection with and without magnification correction. Results: The superficial layer of the macular region was not significantly correlated to the axial length without magnification correction (r = 0.0011; P = 0.99); however, it was negatively correlated to the axial length with magnification correction (r = –0.22; P = 0.028). Regarding the nerve head layer in the circumpapillary region, a negative correlation to the axial length without magnification correction was observed (r = –0.22; P = 0.031); however, this significant correlation disappeared with magnification correction. The superficial layer of the macula and the nerve head layer of the circumpapillary region were significantly correlated to Humphrey 24-2 MS values without magnification correction (r = 0.22 and r = 0.32, respectively); however, these correlations did not improve after magnification correction (r = 0.20 and r = 0.33, respectively). Glaucoma diagnostic accuracy in the superficial layer (AUC, 0.63) and nerve head layer (AUC, 0.70) without magnification correction did not improve after magnification correction (AUC, 0.62 and 0.69, respectively). Conclusions: Adjustment of the ocular magnification is important for accurate VD measurements; however, it may not significantly impact structure–function relationships and glaucoma detection. |
| first_indexed | 2024-12-12T15:34:32Z |
| format | Article |
| id | doaj.art-a72c7e038b3b4649ab6bef338c03179f |
| institution | Directory Open Access Journal |
| issn | 2666-9145 |
| language | English |
| last_indexed | 2024-12-12T15:34:32Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ophthalmology Science |
| spelling | doaj.art-a72c7e038b3b4649ab6bef338c03179f2022-12-22T00:20:03ZengElsevierOphthalmology Science2666-91452022-06-0122100120Structure–Function Relationships and Glaucoma Detection with Magnification Correction of OCT AngiographyKazunori Hirasawa, CO, PhD0Jun Yamaguchi, CO1Koichi Nagano, CO2Junji Kanno, CO3Masayuki Kasahara, MD, PhD4Nobuyuki Shoji, MD, PhD5Department of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan; Correspondence: Kazunori Hirasawa, OD, PhD, Department of Ophthalmology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan.Department of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Kanagawa, JapanDepartment of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Kanagawa, JapanDepartment of Ophthalmology, Saitama Medical University, Iruma, Saitama, JapanDepartment of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Kanagawa, JapanDepartment of Ophthalmology, Kitasato University School of Medicine, Sagamihara, Kanagawa, JapanPurpose: To investigate the effects of adjusting the ocular magnification during OCT-based angiography imaging on structure–function relationships and glaucoma detection. Design: Cross-sectional study. Participants: A total of 96 healthy control participants and 90 patients with open-angle glaucoma were included. Methods: One eye of each patient in the control group and the patient group was evaluated. The layers comprising the macula vascular density (VD) and circumpapillary VD were derived from swept-source OCT angiography imaging. The mean sensitivity (MS) of the standard automated perimetry was measured using the Humphrey 24-2 test. Structure–function relationships were evaluated with simple and partial correlation coefficients. A receiver operating characteristic analysis was performed to evaluate the diagnostic accuracy for glaucoma using the area under the receiver operating characteristic curve (AUC). Ocular magnification was adjusted using Littmann’s formula modified by Bennett. Main Outcome Measures: The association between the axial length and VD, structure–function relationships, and glaucoma detection with and without magnification correction. Results: The superficial layer of the macular region was not significantly correlated to the axial length without magnification correction (r = 0.0011; P = 0.99); however, it was negatively correlated to the axial length with magnification correction (r = –0.22; P = 0.028). Regarding the nerve head layer in the circumpapillary region, a negative correlation to the axial length without magnification correction was observed (r = –0.22; P = 0.031); however, this significant correlation disappeared with magnification correction. The superficial layer of the macula and the nerve head layer of the circumpapillary region were significantly correlated to Humphrey 24-2 MS values without magnification correction (r = 0.22 and r = 0.32, respectively); however, these correlations did not improve after magnification correction (r = 0.20 and r = 0.33, respectively). Glaucoma diagnostic accuracy in the superficial layer (AUC, 0.63) and nerve head layer (AUC, 0.70) without magnification correction did not improve after magnification correction (AUC, 0.62 and 0.69, respectively). Conclusions: Adjustment of the ocular magnification is important for accurate VD measurements; however, it may not significantly impact structure–function relationships and glaucoma detection.http://www.sciencedirect.com/science/article/pii/S2666914522000094Early glaucomaGlaucoma detectionOCT angiographyOcular magnification |
| spellingShingle | Kazunori Hirasawa, CO, PhD Jun Yamaguchi, CO Koichi Nagano, CO Junji Kanno, CO Masayuki Kasahara, MD, PhD Nobuyuki Shoji, MD, PhD Structure–Function Relationships and Glaucoma Detection with Magnification Correction of OCT Angiography Ophthalmology Science Early glaucoma Glaucoma detection OCT angiography Ocular magnification |
| title | Structure–Function Relationships and Glaucoma Detection with Magnification Correction of OCT Angiography |
| title_full | Structure–Function Relationships and Glaucoma Detection with Magnification Correction of OCT Angiography |
| title_fullStr | Structure–Function Relationships and Glaucoma Detection with Magnification Correction of OCT Angiography |
| title_full_unstemmed | Structure–Function Relationships and Glaucoma Detection with Magnification Correction of OCT Angiography |
| title_short | Structure–Function Relationships and Glaucoma Detection with Magnification Correction of OCT Angiography |
| title_sort | structure function relationships and glaucoma detection with magnification correction of oct angiography |
| topic | Early glaucoma Glaucoma detection OCT angiography Ocular magnification |
| url | http://www.sciencedirect.com/science/article/pii/S2666914522000094 |
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