Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes—Recent Advances
Di(hetero)aryl ketones are important motifs present in natural products, pharmaceuticals or agrochemicals. In recent years, Pd(II)-catalyzed acylation of (hetero)arenes in the presence of an oxidant has emerged as a catalytic alternative to classical acylation methods, reducing the production of tox...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/14/3247 |
| _version_ | 1797562279586168832 |
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| author | Carlos Santiago Nuria Sotomayor Esther Lete |
| author_facet | Carlos Santiago Nuria Sotomayor Esther Lete |
| author_sort | Carlos Santiago |
| collection | DOAJ |
| description | Di(hetero)aryl ketones are important motifs present in natural products, pharmaceuticals or agrochemicals. In recent years, Pd(II)-catalyzed acylation of (hetero)arenes in the presence of an oxidant has emerged as a catalytic alternative to classical acylation methods, reducing the production of toxic metal waste. Different directing groups and acyl sources are being studied for this purpose, although further development is required to face mainly selectivity problems in order to be applied in the synthesis of more complex molecules. Selected recent developments and applications are covered in this review. |
| first_indexed | 2024-03-10T18:26:01Z |
| format | Article |
| id | doaj.art-a72f17c41f3b48238c0483dffcde7386 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:26:01Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a72f17c41f3b48238c0483dffcde73862023-11-20T07:00:43ZengMDPI AGMolecules1420-30492020-07-012514324710.3390/molecules25143247Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes—Recent AdvancesCarlos Santiago0Nuria Sotomayor1Esther Lete2Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU. Apdo. 644. 48080 Bilbao, SpainDepartamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU. Apdo. 644. 48080 Bilbao, SpainDepartamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU. Apdo. 644. 48080 Bilbao, SpainDi(hetero)aryl ketones are important motifs present in natural products, pharmaceuticals or agrochemicals. In recent years, Pd(II)-catalyzed acylation of (hetero)arenes in the presence of an oxidant has emerged as a catalytic alternative to classical acylation methods, reducing the production of toxic metal waste. Different directing groups and acyl sources are being studied for this purpose, although further development is required to face mainly selectivity problems in order to be applied in the synthesis of more complex molecules. Selected recent developments and applications are covered in this review.https://www.mdpi.com/1420-3049/25/14/3247C-H activationacylationpalladiumarenesheteroarenes |
| spellingShingle | Carlos Santiago Nuria Sotomayor Esther Lete Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes—Recent Advances Molecules C-H activation acylation palladium arenes heteroarenes |
| title | Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes—Recent Advances |
| title_full | Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes—Recent Advances |
| title_fullStr | Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes—Recent Advances |
| title_full_unstemmed | Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes—Recent Advances |
| title_short | Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes—Recent Advances |
| title_sort | pd ii catalyzed c h acylation of hetero arenes recent advances |
| topic | C-H activation acylation palladium arenes heteroarenes |
| url | https://www.mdpi.com/1420-3049/25/14/3247 |
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