Genetic polymorphisms in tumour necrosis factor receptors (TNFRSF1A/1B) illustrate differential treatment response to TNFα inhibitors in patients with Crohn’s disease

BackgroundMonoclonal antibodies inhibiting tumour necrosis factor-α (TNFα) signalling pathway (anti-TNFα) have been widely used in Crohn’s disease (CD). However, treatment response varies among patients with CD and the clinical outcome is dependent on single nucleotide polymorphisms (SNP) in TNFα r...

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Bibliografiske detaljer
Main Authors: Ahmad Qasem, Saleh A Naser, Seela Ramesh
Format: Article
Sprog:English
Udgivet: BMJ Publishing Group 2019-06-01
Serier:BMJ Open Gastroenterology