HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY
Numerous literature data indicate to gradual, but steady ageependent decrease of immunological reactivity in human organism, manifesting as a reduced ability to develop specific immune response, both of cellular and humoral type. Such negative trends result into increased proposition and frequency o...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-11-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/725 |
| _version_ | 1797198037088468992 |
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| author | V. A. Kozlov |
| author_facet | V. A. Kozlov |
| author_sort | V. A. Kozlov |
| collection | DOAJ |
| description | Numerous literature data indicate to gradual, but steady ageependent decrease of immunological reactivity in human organism, manifesting as a reduced ability to develop specific immune response, both of cellular and humoral type. Such negative trends result into increased proposition and frequency of various diseases, including cancer and autoimmune disorders. Finally, an age-associated immunodeficiency is developed even in normal organism, without clear background of specific disorders. The multicomponent mechanisms of such deficiency are not yet fully clarified. One may assume that, among these potentially leading mechanisms, a homeostatic proliferation may be of sufficient importance. This type of cell growth is shown to accompany any negative effects on the numbers of lymphocytes in the body. It manifests as a reduced ability of lymphocytes to recognize foreign antigens associated with a background increase of self-reactive cells. |
| first_indexed | 2024-03-08T05:49:59Z |
| format | Article |
| id | doaj.art-a731c8e1e4414c31abccee4b6d5c9150 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:29Z |
| publishDate | 2014-11-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-a731c8e1e4414c31abccee4b6d5c91502024-04-22T13:07:39ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-11-0116540340810.15789/1563-0625-2014-5-403-408705HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCYV. A. Kozlov0Research Institute of Clinical Immunology, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, Russian FederationNumerous literature data indicate to gradual, but steady ageependent decrease of immunological reactivity in human organism, manifesting as a reduced ability to develop specific immune response, both of cellular and humoral type. Such negative trends result into increased proposition and frequency of various diseases, including cancer and autoimmune disorders. Finally, an age-associated immunodeficiency is developed even in normal organism, without clear background of specific disorders. The multicomponent mechanisms of such deficiency are not yet fully clarified. One may assume that, among these potentially leading mechanisms, a homeostatic proliferation may be of sufficient importance. This type of cell growth is shown to accompany any negative effects on the numbers of lymphocytes in the body. It manifests as a reduced ability of lymphocytes to recognize foreign antigens associated with a background increase of self-reactive cells.https://www.mimmun.ru/mimmun/article/view/725homeostatic proliferationimmunodeficiencyna ve t cellsmemory t cellsapoptosis |
| spellingShingle | V. A. Kozlov HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY Медицинская иммунология homeostatic proliferation immunodeficiency na ve t cells memory t cells apoptosis |
| title | HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY |
| title_full | HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY |
| title_fullStr | HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY |
| title_full_unstemmed | HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY |
| title_short | HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY |
| title_sort | homeostatc proliferation as a basis for the inevitable formation of total immunodeficiency |
| topic | homeostatic proliferation immunodeficiency na ve t cells memory t cells apoptosis |
| url | https://www.mimmun.ru/mimmun/article/view/725 |
| work_keys_str_mv | AT vakozlov homeostatcproliferationasabasisfortheinevitableformationoftotalimmunodeficiency |