Integrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death.

Integrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death.

Sound perception requires functional hair cell mechanotransduction (MET) machinery, including the MET channels and tip-link proteins. Prior work showed that uptake of ototoxic aminoglycosides (AG) into hair cells requires functional MET channels. In this study, we examined whether tip-link proteins,...

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Bibliographic Details
Main Authors: Andrew A Vu, Garani S Nadaraja, Markus E Huth, Lauren Luk, John Kim, Renjie Chai, Anthony J Ricci, Alan G Cheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3554584?pdf=render

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