Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020
There is a growing interest in echovirus 30 (E30), an enterovirus responsible for neurological disease and hospitalization. There are multiple studies of outbreaks, but few that study the epidemiology over long periods of time. Our study aims to describe the clinical, epidemiological and microbiolog...
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MDPI AG
2022-03-01
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| Online Access: | https://www.mdpi.com/2076-2607/10/3/592 |
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| author | Margarita del Cuerpo Jon Gonzalez de Audicana Maria Dolores Fernandez-Garcia Pilar Marín Montserrat Esteban Montserrat Español María Cabrerizo Núria Rabella |
| author_facet | Margarita del Cuerpo Jon Gonzalez de Audicana Maria Dolores Fernandez-Garcia Pilar Marín Montserrat Esteban Montserrat Español María Cabrerizo Núria Rabella |
| author_sort | Margarita del Cuerpo |
| collection | DOAJ |
| description | There is a growing interest in echovirus 30 (E30), an enterovirus responsible for neurological disease and hospitalization. There are multiple studies of outbreaks, but few that study the epidemiology over long periods of time. Our study aims to describe the clinical, epidemiological and microbiological characteristics of a series of E30 infections detected over 26 years. Data were retrospectively collected from a database of all enterovirus infections identified in our laboratory. They were detected by viral isolation or nucleic acid detection in patients presenting with respiratory or neurological infections, rash, sepsis-like syndrome, or gastroenteritis. Enterovirus genotyping was performed by amplification of the VP1 gene using RT-nested PCR, followed by sequencing and BLAST analysis. Of the 2402 enterovirus infections detected, 1619 were linked to at least one genotype and 173 were caused by E30. Clinical information was available for 158 (91.3%) patients. E30 was associated with neurological infection in 107 (67.8%) cases and it was detected almost every year. Phylogenetic analysis was performed with 67 sequences. We observed that E30 strains circulating in Catalonia from 1996 to 2016 belong to two lineages (E and F), although the majority cluster was in F. In 2018, lineage I emerged as the dominant lineage. |
| first_indexed | 2024-03-09T13:15:44Z |
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| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T13:15:44Z |
| publishDate | 2022-03-01 |
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| spelling | doaj.art-a7335e2b22af4f7fb068edd23d8f7f122023-11-30T21:36:34ZengMDPI AGMicroorganisms2076-26072022-03-0110359210.3390/microorganisms10030592Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020Margarita del Cuerpo0Jon Gonzalez de Audicana1Maria Dolores Fernandez-Garcia2Pilar Marín3Montserrat Esteban4Montserrat Español5María Cabrerizo6Núria Rabella7Microbiology Department, Hospital de la Santa Creu i Sant Pau, Sant Pau Biomedical Research Institute (IIB Sant Pau), 08041 Barcelona, SpainEnterovirus and Viral Gastroenteritis Unit, National Centre for Microbiology, Instituto de Salud Carlos III, 28222 Madrid, SpainEnterovirus and Viral Gastroenteritis Unit, National Centre for Microbiology, Instituto de Salud Carlos III, 28222 Madrid, SpainMicrobiology Department, Hospital de la Santa Creu i Sant Pau, Sant Pau Biomedical Research Institute (IIB Sant Pau), 08041 Barcelona, SpainMicrobiology Department, Hospital de la Santa Creu i Sant Pau, Sant Pau Biomedical Research Institute (IIB Sant Pau), 08041 Barcelona, SpainMicrobiology Department, Hospital de la Santa Creu i Sant Pau, Sant Pau Biomedical Research Institute (IIB Sant Pau), 08041 Barcelona, SpainEnterovirus and Viral Gastroenteritis Unit, National Centre for Microbiology, Instituto de Salud Carlos III, 28222 Madrid, SpainMicrobiology Department, Hospital de la Santa Creu i Sant Pau, Sant Pau Biomedical Research Institute (IIB Sant Pau), 08041 Barcelona, SpainThere is a growing interest in echovirus 30 (E30), an enterovirus responsible for neurological disease and hospitalization. There are multiple studies of outbreaks, but few that study the epidemiology over long periods of time. Our study aims to describe the clinical, epidemiological and microbiological characteristics of a series of E30 infections detected over 26 years. Data were retrospectively collected from a database of all enterovirus infections identified in our laboratory. They were detected by viral isolation or nucleic acid detection in patients presenting with respiratory or neurological infections, rash, sepsis-like syndrome, or gastroenteritis. Enterovirus genotyping was performed by amplification of the VP1 gene using RT-nested PCR, followed by sequencing and BLAST analysis. Of the 2402 enterovirus infections detected, 1619 were linked to at least one genotype and 173 were caused by E30. Clinical information was available for 158 (91.3%) patients. E30 was associated with neurological infection in 107 (67.8%) cases and it was detected almost every year. Phylogenetic analysis was performed with 67 sequences. We observed that E30 strains circulating in Catalonia from 1996 to 2016 belong to two lineages (E and F), although the majority cluster was in F. In 2018, lineage I emerged as the dominant lineage.https://www.mdpi.com/2076-2607/10/3/592enterovirusesechovirus 30central nervous systemcerebrospinal fluidphylogenetic analysisepidemiology |
| spellingShingle | Margarita del Cuerpo Jon Gonzalez de Audicana Maria Dolores Fernandez-Garcia Pilar Marín Montserrat Esteban Montserrat Español María Cabrerizo Núria Rabella Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020 Microorganisms enteroviruses echovirus 30 central nervous system cerebrospinal fluid phylogenetic analysis epidemiology |
| title | Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020 |
| title_full | Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020 |
| title_fullStr | Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020 |
| title_full_unstemmed | Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020 |
| title_short | Epidemiology of Echovirus 30 Infections Detected in a University Hospital in Catalonia, Spain, in 1995–2020 |
| title_sort | epidemiology of echovirus 30 infections detected in a university hospital in catalonia spain in 1995 2020 |
| topic | enteroviruses echovirus 30 central nervous system cerebrospinal fluid phylogenetic analysis epidemiology |
| url | https://www.mdpi.com/2076-2607/10/3/592 |
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