Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant
Abstract Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, however, they often pose interpretive challenges. We systematically reviewed the pre-print and published literature for neutralization studies against Omicron using sera co...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-022-00565-y |
| _version_ | 1797429437477683200 |
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| author | Ioannis Sitaras Henning Jacobsen Melissa M. Higdon William E. Dowling Naor Bar-Zeev Maria Deloria Knoll |
| author_facet | Ioannis Sitaras Henning Jacobsen Melissa M. Higdon William E. Dowling Naor Bar-Zeev Maria Deloria Knoll |
| author_sort | Ioannis Sitaras |
| collection | DOAJ |
| description | Abstract Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, however, they often pose interpretive challenges. We systematically reviewed the pre-print and published literature for neutralization studies against Omicron using sera collected after both primary and booster vaccination. We found a high proportion of post-primary vaccination sera were not responding against Omicron but boosting increased both neutralizing activity and percent of responding sera. We recommend reporting percent of responders alongside neutralization data to portray vaccine neutralization ability more accurately. |
| first_indexed | 2024-03-09T09:13:10Z |
| format | Article |
| id | doaj.art-a7351475615c4558bef1b79444dde9bd |
| institution | Directory Open Access Journal |
| issn | 2059-0105 |
| language | English |
| last_indexed | 2024-03-09T09:13:10Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj.art-a7351475615c4558bef1b79444dde9bd2023-12-02T08:16:26ZengNature Portfolionpj Vaccines2059-01052022-11-01711510.1038/s41541-022-00565-ySystematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variantIoannis Sitaras0Henning Jacobsen1Melissa M. Higdon2William E. Dowling3Naor Bar-Zeev4Maria Deloria Knoll5W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public HealthDepartment of Viral Immunology, Helmholtz Centre for Infection ResearchInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public HealthCoalition for Epidemic Preparedness InnovationsInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public HealthInternational Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public HealthAbstract Virus neutralization data using post-vaccination sera are an important tool in informing vaccine use policy decisions, however, they often pose interpretive challenges. We systematically reviewed the pre-print and published literature for neutralization studies against Omicron using sera collected after both primary and booster vaccination. We found a high proportion of post-primary vaccination sera were not responding against Omicron but boosting increased both neutralizing activity and percent of responding sera. We recommend reporting percent of responders alongside neutralization data to portray vaccine neutralization ability more accurately.https://doi.org/10.1038/s41541-022-00565-y |
| spellingShingle | Ioannis Sitaras Henning Jacobsen Melissa M. Higdon William E. Dowling Naor Bar-Zeev Maria Deloria Knoll Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant npj Vaccines |
| title | Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant |
| title_full | Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant |
| title_fullStr | Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant |
| title_full_unstemmed | Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant |
| title_short | Systematic review of primary and booster COVID-19 sera neutralizing ability against SARS-CoV-2 omicron variant |
| title_sort | systematic review of primary and booster covid 19 sera neutralizing ability against sars cov 2 omicron variant |
| url | https://doi.org/10.1038/s41541-022-00565-y |
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