Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis

Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis

Abstract Background Pancreatic cancer is a highly lethal disease with no effective treatments. Lactobacillus casei (L. casei) and Lactobacillus reuteri (L. reuteri) exhibited therapeutic effects on several cancers, but their roles in pancreatic cancer are unknown. This study aims to explore how L. c...

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Bibliographic Details
Main Authors: Zemin Zhu, Bo Yi, Zikai Tang, Xun Chen, Ming Li, Tao Xu, Zhijian Zhao, Caixi Tang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Cancer
Subjects:
Lactobacillus casei
Lactobacillus reuteri
TLR4
Macrophage polarization
Gut microbial homeostasis
Online Access:https://doi.org/10.1186/s12885-023-11557-z

Internet

https://doi.org/10.1186/s12885-023-11557-z

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