The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects
Aim: To analyze age-related cerebral blood flow (CBF) using arterial spin labeling (ASL) MRI in healthy subjects with multivariate principal component analysis (PCA).Methods: 50 healthy subjects (mean age 45.8 ± 18.5 years, range 21–85) had 3D structural MRI and pseudo-continuous ASL MRI at resting...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2018.00214/full |
| _version_ | 1817984363918262272 |
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| author | Nan Zhang Nan Zhang Marc L. Gordon Marc L. Gordon Yilong Ma Bradley Chi Jesus J. Gomar Shichun Peng Peter B. Kingsley Peter B. Kingsley David Eidelberg David Eidelberg Terry E. Goldberg Terry E. Goldberg |
| author_facet | Nan Zhang Nan Zhang Marc L. Gordon Marc L. Gordon Yilong Ma Bradley Chi Jesus J. Gomar Shichun Peng Peter B. Kingsley Peter B. Kingsley David Eidelberg David Eidelberg Terry E. Goldberg Terry E. Goldberg |
| author_sort | Nan Zhang |
| collection | DOAJ |
| description | Aim: To analyze age-related cerebral blood flow (CBF) using arterial spin labeling (ASL) MRI in healthy subjects with multivariate principal component analysis (PCA).Methods: 50 healthy subjects (mean age 45.8 ± 18.5 years, range 21–85) had 3D structural MRI and pseudo-continuous ASL MRI at resting state. The relationship between CBF and age was examined with voxel-based univariate analysis using multiple regression and two-sample t-test (median age 41.8 years as a cut-off). An age-related CBF pattern was identified using multivariate PCA.Results: Age correlated negatively with CBF especially anteriorly and in the cerebellum. After adjusting by global value, CBF was relatively decreased with aging in certain regions and relatively increased in others. The age-related CBF pattern showed relative reductions in frontal and parietal areas and cerebellum, and covarying increases in temporal and occipital areas. Subject scores of this pattern correlated negatively with age (R2 = 0.588; P < 0.001) and discriminated between the older and younger subgroups (P < 0.001).Conclusion: A distinct age-related CBF pattern can be identified with multivariate PCA using ASL MRI. |
| first_indexed | 2024-04-13T23:44:43Z |
| format | Article |
| id | doaj.art-a7365ff7ccd1489982017a266d613627 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T23:44:43Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-a7365ff7ccd1489982017a266d6136272022-12-22T02:24:23ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-07-011010.3389/fnagi.2018.00214347110The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy SubjectsNan Zhang0Nan Zhang1Marc L. Gordon2Marc L. Gordon3Yilong Ma4Bradley Chi5Jesus J. Gomar6Shichun Peng7Peter B. Kingsley8Peter B. Kingsley9David Eidelberg10David Eidelberg11Terry E. Goldberg12Terry E. Goldberg13The Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United StatesDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, ChinaThe Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United StatesDonald and Barbara Zucker School of Medicine at Hofstra-Northwell, Hofstra University, Hepstead, NY, United StatesCenter for Neurosciences, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United StatesDonald and Barbara Zucker School of Medicine at Hofstra-Northwell, Hofstra University, Hepstead, NY, United StatesThe Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United StatesCenter for Neurosciences, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United StatesDonald and Barbara Zucker School of Medicine at Hofstra-Northwell, Hofstra University, Hepstead, NY, United StatesDepartment of Radiology, North Shore University Hospital, Northwell Health, Manhasset, NY, United StatesDonald and Barbara Zucker School of Medicine at Hofstra-Northwell, Hofstra University, Hepstead, NY, United StatesCenter for Neurosciences, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United StatesThe Litwin-Zucker Research Center, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United StatesDonald and Barbara Zucker School of Medicine at Hofstra-Northwell, Hofstra University, Hepstead, NY, United StatesAim: To analyze age-related cerebral blood flow (CBF) using arterial spin labeling (ASL) MRI in healthy subjects with multivariate principal component analysis (PCA).Methods: 50 healthy subjects (mean age 45.8 ± 18.5 years, range 21–85) had 3D structural MRI and pseudo-continuous ASL MRI at resting state. The relationship between CBF and age was examined with voxel-based univariate analysis using multiple regression and two-sample t-test (median age 41.8 years as a cut-off). An age-related CBF pattern was identified using multivariate PCA.Results: Age correlated negatively with CBF especially anteriorly and in the cerebellum. After adjusting by global value, CBF was relatively decreased with aging in certain regions and relatively increased in others. The age-related CBF pattern showed relative reductions in frontal and parietal areas and cerebellum, and covarying increases in temporal and occipital areas. Subject scores of this pattern correlated negatively with age (R2 = 0.588; P < 0.001) and discriminated between the older and younger subgroups (P < 0.001).Conclusion: A distinct age-related CBF pattern can be identified with multivariate PCA using ASL MRI.https://www.frontiersin.org/article/10.3389/fnagi.2018.00214/fullarterial spin labelingcerebral blood flowagingprincipal component analysisscaled subprofile model |
| spellingShingle | Nan Zhang Nan Zhang Marc L. Gordon Marc L. Gordon Yilong Ma Bradley Chi Jesus J. Gomar Shichun Peng Peter B. Kingsley Peter B. Kingsley David Eidelberg David Eidelberg Terry E. Goldberg Terry E. Goldberg The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects Frontiers in Aging Neuroscience arterial spin labeling cerebral blood flow aging principal component analysis scaled subprofile model |
| title | The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects |
| title_full | The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects |
| title_fullStr | The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects |
| title_full_unstemmed | The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects |
| title_short | The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling MRI in Healthy Subjects |
| title_sort | age related perfusion pattern measured with arterial spin labeling mri in healthy subjects |
| topic | arterial spin labeling cerebral blood flow aging principal component analysis scaled subprofile model |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2018.00214/full |
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