Association of trabecular meshwork height with steroid-induced ocular hypertension
Abstract It is important to identify at-risk patients prior to administering steroid injections to prevent avoidable irreversible blindness inducted by steroid-induced ocular hypertension (SIOH). We aimed to investigate the association of SIOH following intravitreal dexamethasone implantation (OZURD...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-36329-4 |
| _version_ | 1827928646588825600 |
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| author | Won Jeong Cho Yitak Kim Jung Dong Kim Eun Woo Kim Hyoung Won Bae Chan Yun Kim Wungrak Choi |
| author_facet | Won Jeong Cho Yitak Kim Jung Dong Kim Eun Woo Kim Hyoung Won Bae Chan Yun Kim Wungrak Choi |
| author_sort | Won Jeong Cho |
| collection | DOAJ |
| description | Abstract It is important to identify at-risk patients prior to administering steroid injections to prevent avoidable irreversible blindness inducted by steroid-induced ocular hypertension (SIOH). We aimed to investigate the association of SIOH following intravitreal dexamethasone implantation (OZURDEX) using anterior segment optical coherence tomography (AS-OCT). We conducted a retrospective case control study to assess the association between trabecular meshwork and SIOH. A total of 102 eyes that underwent both AS-OCT and intravitreal dexamethasone implant injection were divided into the post-steroid ocular hypertension and normal intraocular pressure groups. Ocular parameters that can contribute to intraocular pressure were measured using AS-OCT. Univariable logistic regression analysis was used to calculate the odds ratio of the SIOH and significant variables were further analyzed using a multivariable model. Trabecular meshwork (TM) height was significantly shorter in the ocular hypertension group (716.13 ± 80.55 μm) than that in the normal intraocular pressure group (784.27 ± 82.33 μm) (p < 0.001). The receiver operating characteristic curve technique analysis showed that the optimal cut-off of ≥ 802.13 μm for TM height specificity was 96.2%, and TM height with < 646.75 μm had a sensitivity of 94.70%. The odds ratio of the association was 0.990 (p = 0.001). TM height was identified as a newly observed association with SIOH. TM height can be assessed using AS-OCT, with acceptable sensitivity and specificity. Caution must be exercised while injecting steroids in patients with short TM height (especially < 646.75 μm) as it may cause SIOH and irreversible blindness. |
| first_indexed | 2024-03-13T06:11:42Z |
| format | Article |
| id | doaj.art-a737b14ed38949ef9a9bf8d46d4780c6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T06:11:42Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a737b14ed38949ef9a9bf8d46d4780c62023-06-11T11:14:10ZengNature PortfolioScientific Reports2045-23222023-06-011311910.1038/s41598-023-36329-4Association of trabecular meshwork height with steroid-induced ocular hypertensionWon Jeong Cho0Yitak Kim1Jung Dong Kim2Eun Woo Kim3Hyoung Won Bae4Chan Yun Kim5Wungrak Choi6Department of Ophthalmology, Institute of Vision Research, Yonsei University College of MedicineDepartment of Ophthalmology, Institute of Vision Research, Yonsei University College of MedicineDepartment of Ophthalmology, Institute of Vision Research, Yonsei University College of MedicineDepartment of Ophthalmology, Institute of Vision Research, Yonsei University College of MedicineDepartment of Ophthalmology, Institute of Vision Research, Yonsei University College of MedicineDepartment of Ophthalmology, Institute of Vision Research, Yonsei University College of MedicineDepartment of Ophthalmology, Institute of Vision Research, Yonsei University College of MedicineAbstract It is important to identify at-risk patients prior to administering steroid injections to prevent avoidable irreversible blindness inducted by steroid-induced ocular hypertension (SIOH). We aimed to investigate the association of SIOH following intravitreal dexamethasone implantation (OZURDEX) using anterior segment optical coherence tomography (AS-OCT). We conducted a retrospective case control study to assess the association between trabecular meshwork and SIOH. A total of 102 eyes that underwent both AS-OCT and intravitreal dexamethasone implant injection were divided into the post-steroid ocular hypertension and normal intraocular pressure groups. Ocular parameters that can contribute to intraocular pressure were measured using AS-OCT. Univariable logistic regression analysis was used to calculate the odds ratio of the SIOH and significant variables were further analyzed using a multivariable model. Trabecular meshwork (TM) height was significantly shorter in the ocular hypertension group (716.13 ± 80.55 μm) than that in the normal intraocular pressure group (784.27 ± 82.33 μm) (p < 0.001). The receiver operating characteristic curve technique analysis showed that the optimal cut-off of ≥ 802.13 μm for TM height specificity was 96.2%, and TM height with < 646.75 μm had a sensitivity of 94.70%. The odds ratio of the association was 0.990 (p = 0.001). TM height was identified as a newly observed association with SIOH. TM height can be assessed using AS-OCT, with acceptable sensitivity and specificity. Caution must be exercised while injecting steroids in patients with short TM height (especially < 646.75 μm) as it may cause SIOH and irreversible blindness.https://doi.org/10.1038/s41598-023-36329-4 |
| spellingShingle | Won Jeong Cho Yitak Kim Jung Dong Kim Eun Woo Kim Hyoung Won Bae Chan Yun Kim Wungrak Choi Association of trabecular meshwork height with steroid-induced ocular hypertension Scientific Reports |
| title | Association of trabecular meshwork height with steroid-induced ocular hypertension |
| title_full | Association of trabecular meshwork height with steroid-induced ocular hypertension |
| title_fullStr | Association of trabecular meshwork height with steroid-induced ocular hypertension |
| title_full_unstemmed | Association of trabecular meshwork height with steroid-induced ocular hypertension |
| title_short | Association of trabecular meshwork height with steroid-induced ocular hypertension |
| title_sort | association of trabecular meshwork height with steroid induced ocular hypertension |
| url | https://doi.org/10.1038/s41598-023-36329-4 |
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