Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies

Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies

Cancer immunotherapy strategies based on the endogenous secretion of T cell-redirecting bispecific antibodies by engineered T lymphocytes (STAb-T) are emerging as alternative or complementary approaches to those based on chimeric antigen receptors (CAR-T). The antitumor efficacy of bispecific anti-C...

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Bibliographic Details
Main Authors: Ángel Ramírez-Fernández, Óscar Aguilar-Sopeña, Laura Díez-Alonso, Alejandro Segura-Tudela, Carmen Domínguez-Alonso, Pedro Roda-Navarro, Luis Álvarez-Vallina, Belén Blanco
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
CD19+ B cell malignancies
T cell-redirecting strategies
STAb
BiTE
CAR
leukemia relapse
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2054106

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