Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database
Objective:This study aims to analyze adverse drug events (ADEs) associated with cenobamate from the FAERS database, covering the third quarter of 2020 to the second quarter of 2023.Methods:Data related to cenobamate-associated ADEs from the third quarter of 2020 to the second quarter of 2023 were co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1369384/full |
| _version_ | 1797261793798651904 |
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| author | Shihao Chen Wenqiang Fang Linqian Zhao Huiqin Xu |
| author_facet | Shihao Chen Wenqiang Fang Linqian Zhao Huiqin Xu |
| author_sort | Shihao Chen |
| collection | DOAJ |
| description | Objective:This study aims to analyze adverse drug events (ADEs) associated with cenobamate from the FAERS database, covering the third quarter of 2020 to the second quarter of 2023.Methods:Data related to cenobamate-associated ADEs from the third quarter of 2020 to the second quarter of 2023 were collected. After standardizing the data, various signal quantification techniques, including ROR, MHRA, BCPNN, and MGPS, were employed for analysis.Results:Among 2535 ADE reports where cenobamate was the primary suspected drug, 94 adverse reactions involving 11 different System Organ Class (SOC) categories were identified through the application of four signal quantification techniques. More specifically, neurological disorders and injuries resultant from complications are frequent adverse reactions associated with cenobamate.Conclusion:Our research findings align with established results, affirming the favorable safety profile of cenobamate. Effective prevention of adverse reactions induced by cenobamate can be achieved through the establishment of efficient blood concentration monitoring and dose adjustments. |
| first_indexed | 2024-04-24T23:46:52Z |
| format | Article |
| id | doaj.art-a73840d2097a413396ff3ed260769e20 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-24T23:46:52Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a73840d2097a413396ff3ed260769e202024-03-15T04:59:46ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-03-011510.3389/fphar.2024.13693841369384Safety assessment of cenobamate: real-world adverse event analysis from the FAERS databaseShihao ChenWenqiang FangLinqian ZhaoHuiqin XuObjective:This study aims to analyze adverse drug events (ADEs) associated with cenobamate from the FAERS database, covering the third quarter of 2020 to the second quarter of 2023.Methods:Data related to cenobamate-associated ADEs from the third quarter of 2020 to the second quarter of 2023 were collected. After standardizing the data, various signal quantification techniques, including ROR, MHRA, BCPNN, and MGPS, were employed for analysis.Results:Among 2535 ADE reports where cenobamate was the primary suspected drug, 94 adverse reactions involving 11 different System Organ Class (SOC) categories were identified through the application of four signal quantification techniques. More specifically, neurological disorders and injuries resultant from complications are frequent adverse reactions associated with cenobamate.Conclusion:Our research findings align with established results, affirming the favorable safety profile of cenobamate. Effective prevention of adverse reactions induced by cenobamate can be achieved through the establishment of efficient blood concentration monitoring and dose adjustments.https://www.frontiersin.org/articles/10.3389/fphar.2024.1369384/fullFAERS databasecenobamateadverse drug eventsepilepsyreal-world study |
| spellingShingle | Shihao Chen Wenqiang Fang Linqian Zhao Huiqin Xu Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database Frontiers in Pharmacology FAERS database cenobamate adverse drug events epilepsy real-world study |
| title | Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database |
| title_full | Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database |
| title_fullStr | Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database |
| title_full_unstemmed | Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database |
| title_short | Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database |
| title_sort | safety assessment of cenobamate real world adverse event analysis from the faers database |
| topic | FAERS database cenobamate adverse drug events epilepsy real-world study |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1369384/full |
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