Frequent cleft lip and palate in families with pathogenic germline CDH1 variants

Frequent cleft lip and palate in families with pathogenic germline CDH1 variants

Pathogenic and likely pathogenic (P/LP) germline variants in the tumor suppressor gene CDH1 (E-cadherin) result in increased lifetime risk of diffuse-type gastric cancer and lobular breast cancer. CDH1 variants are also associated with hereditary cleft lip and palate (CLP), the mechanism of which is...

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Bibliographic Details
Main Authors: Benjamin L. Green, Grace-Ann Fasaye, Sarah G. Samaranayake, Anna Duemler, Lauren A. Gamble, Jeremy L. Davis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Genetics
Subjects:
cleft lip
cleft palate
CDH1
E-cadherin
cleft lip/palate
hereditary diffuse gastric cancer syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1012025/full

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