Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells
The mesenchymal stem cells have multidirectional differentiation potential and can differentiate into adipocytes, osteoblasts, cartilage tissue, muscle cells and so on. The adipogenic differentiation of mesenchymal stem cells is of great significance for the construction of tissue-engineered fat and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.649552/full |
| _version_ | 1818449309879762944 |
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| author | Yuxuan Zhong Xiang Li Fanglin Wang Shoushuai Wang Xiaohong Wang Xiaohong Tian Shuling Bai Di Miao Jun Fan |
| author_facet | Yuxuan Zhong Xiang Li Fanglin Wang Shoushuai Wang Xiaohong Wang Xiaohong Tian Shuling Bai Di Miao Jun Fan |
| author_sort | Yuxuan Zhong |
| collection | DOAJ |
| description | The mesenchymal stem cells have multidirectional differentiation potential and can differentiate into adipocytes, osteoblasts, cartilage tissue, muscle cells and so on. The adipogenic differentiation of mesenchymal stem cells is of great significance for the construction of tissue-engineered fat and the treatment of soft tissue defects. Exosomes are nanoscale vesicles secreted by cells and widely exist in body fluids. They are mainly involved in cell communication processes and transferring cargo contents to recipient cells. In addition, exosomes can also promote tissue and organ regeneration. Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. In this review, the effects of exosomes on stem cell differentiation, especially on adipogenic differentiation, will be discussed, and the mechanisms and conclusions will be drawn. The main purpose of studying the role of these exosomes is to understand more comprehensively the influencing factors existing in the process of stem cell differentiation into adipocytes and provide a new idea in adipose tissue engineering research. |
| first_indexed | 2024-12-14T20:33:22Z |
| format | Article |
| id | doaj.art-a73a87fb682c4962bd137317f19e4d4c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-14T20:33:22Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-a73a87fb682c4962bd137317f19e4d4c2022-12-21T22:48:28ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-06-01910.3389/fcell.2021.649552649552Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem CellsYuxuan Zhong0Xiang Li1Fanglin Wang2Shoushuai Wang3Xiaohong Wang4Xiaohong Tian5Shuling Bai6Di Miao7Jun Fan8Department of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaDepartment of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, ChinaDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaChina Medical University–The Queen’s University of Belfast Joint College–Combination, Shenyang, ChinaDepartment of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, ChinaThe mesenchymal stem cells have multidirectional differentiation potential and can differentiate into adipocytes, osteoblasts, cartilage tissue, muscle cells and so on. The adipogenic differentiation of mesenchymal stem cells is of great significance for the construction of tissue-engineered fat and the treatment of soft tissue defects. Exosomes are nanoscale vesicles secreted by cells and widely exist in body fluids. They are mainly involved in cell communication processes and transferring cargo contents to recipient cells. In addition, exosomes can also promote tissue and organ regeneration. Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. In this review, the effects of exosomes on stem cell differentiation, especially on adipogenic differentiation, will be discussed, and the mechanisms and conclusions will be drawn. The main purpose of studying the role of these exosomes is to understand more comprehensively the influencing factors existing in the process of stem cell differentiation into adipocytes and provide a new idea in adipose tissue engineering research.https://www.frontiersin.org/articles/10.3389/fcell.2021.649552/fullexosomesmesenchymal stem celladipogenic differentiationadipogenesisregenerative medicine |
| spellingShingle | Yuxuan Zhong Xiang Li Fanglin Wang Shoushuai Wang Xiaohong Wang Xiaohong Tian Shuling Bai Di Miao Jun Fan Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells Frontiers in Cell and Developmental Biology exosomes mesenchymal stem cell adipogenic differentiation adipogenesis regenerative medicine |
| title | Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells |
| title_full | Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells |
| title_fullStr | Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells |
| title_full_unstemmed | Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells |
| title_short | Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells |
| title_sort | emerging potential of exosomes on adipogenic differentiation of mesenchymal stem cells |
| topic | exosomes mesenchymal stem cell adipogenic differentiation adipogenesis regenerative medicine |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.649552/full |
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