Effect of allisartan on blood pressure and left ventricular hypertrophy through Kv1.5 channels in hypertensive rats
Background The objective of the present work was to study the anti-hypertensive effect of allisartan on blood pressure (BP) and in facilitating left ventricular remodeling through voltage-gated potassium channels (Kv) 1.5 channels. Methods A total of 30 SD rats were randomly divided into sham operat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-04-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2021.2018597 |
| _version_ | 1797681114323615744 |
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| author | Chunfang Xu Ziying Zhao Wang Yuan Zhao Fengping Yan Zhiqiang Zhang Xiaoqin |
| author_facet | Chunfang Xu Ziying Zhao Wang Yuan Zhao Fengping Yan Zhiqiang Zhang Xiaoqin |
| author_sort | Chunfang Xu |
| collection | DOAJ |
| description | Background The objective of the present work was to study the anti-hypertensive effect of allisartan on blood pressure (BP) and in facilitating left ventricular remodeling through voltage-gated potassium channels (Kv) 1.5 channels. Methods A total of 30 SD rats were randomly divided into sham operation group, hypertension control group, and allisartan treatment group. Hypertension was induced by renal artery stenosis. The animals of treatment group were administered with allisartan once a day at a dose of 30 mg/kg body weight through an oral gavage for 4 weeks. The heart function of animals post 4 weeks of treatment was evaluated by echocardiography, and the degree of ventricular hypertrophy and cardiomyocyte hypertrophy were evaluated by histomorphology. The expression of Kv1.5 is detected by real-time quantitative polymerase chain reaction while Western blotting was used to detect the protein expression. Results Four weeks after renal artery stenosis, a significant difference was observed in the whole heart ratio, left heart ratio, and cardiomyocyte area between allisartan treatment group and the hypertension control group (P< .01). A significant decrease in BP of allisartan treatment group compared to hypertension control group (P< .01) was observed. The expression of Kv1.5 mRNA was increased significantly (P< .01) in allisartan treatment group compared to hypertension control group. Western blot analysis also confirmed the increased expression of Kv1.5 channel. Conclusion The results showed that allisartan lowers BP and improves left ventricular remodeling through increased expression of Kv1.5 mRNA. |
| first_indexed | 2024-03-11T23:40:11Z |
| format | Article |
| id | doaj.art-a73cd77457ba438fa9eb865080d62246 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:40:11Z |
| publishDate | 2022-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-a73cd77457ba438fa9eb865080d622462023-09-19T16:04:07ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062022-04-0144319920710.1080/10641963.2021.20185972018597Effect of allisartan on blood pressure and left ventricular hypertrophy through Kv1.5 channels in hypertensive ratsChunfang Xu0Ziying Zhao1Wang Yuan2Zhao Fengping3Yan Zhiqiang4Zhang Xiaoqin5Southern Medical University Affiliated FengXian HospitalEast Hospital, Tongji University School of MedicineSouthern Medical University Affiliated FengXian HospitalSouthern Medical University Affiliated FengXian HospitalSouthern Medical University Affiliated FengXian HospitalSouthern Medical University Affiliated FengXian HospitalBackground The objective of the present work was to study the anti-hypertensive effect of allisartan on blood pressure (BP) and in facilitating left ventricular remodeling through voltage-gated potassium channels (Kv) 1.5 channels. Methods A total of 30 SD rats were randomly divided into sham operation group, hypertension control group, and allisartan treatment group. Hypertension was induced by renal artery stenosis. The animals of treatment group were administered with allisartan once a day at a dose of 30 mg/kg body weight through an oral gavage for 4 weeks. The heart function of animals post 4 weeks of treatment was evaluated by echocardiography, and the degree of ventricular hypertrophy and cardiomyocyte hypertrophy were evaluated by histomorphology. The expression of Kv1.5 is detected by real-time quantitative polymerase chain reaction while Western blotting was used to detect the protein expression. Results Four weeks after renal artery stenosis, a significant difference was observed in the whole heart ratio, left heart ratio, and cardiomyocyte area between allisartan treatment group and the hypertension control group (P< .01). A significant decrease in BP of allisartan treatment group compared to hypertension control group (P< .01) was observed. The expression of Kv1.5 mRNA was increased significantly (P< .01) in allisartan treatment group compared to hypertension control group. Western blot analysis also confirmed the increased expression of Kv1.5 channel. Conclusion The results showed that allisartan lowers BP and improves left ventricular remodeling through increased expression of Kv1.5 mRNA.http://dx.doi.org/10.1080/10641963.2021.2018597renal artery stenosis hypertensionpotassium channelleft ventricular hypertrophyhypertensionallisartan |
| spellingShingle | Chunfang Xu Ziying Zhao Wang Yuan Zhao Fengping Yan Zhiqiang Zhang Xiaoqin Effect of allisartan on blood pressure and left ventricular hypertrophy through Kv1.5 channels in hypertensive rats Clinical and Experimental Hypertension renal artery stenosis hypertension potassium channel left ventricular hypertrophy hypertension allisartan |
| title | Effect of allisartan on blood pressure and left ventricular hypertrophy through Kv1.5 channels in hypertensive rats |
| title_full | Effect of allisartan on blood pressure and left ventricular hypertrophy through Kv1.5 channels in hypertensive rats |
| title_fullStr | Effect of allisartan on blood pressure and left ventricular hypertrophy through Kv1.5 channels in hypertensive rats |
| title_full_unstemmed | Effect of allisartan on blood pressure and left ventricular hypertrophy through Kv1.5 channels in hypertensive rats |
| title_short | Effect of allisartan on blood pressure and left ventricular hypertrophy through Kv1.5 channels in hypertensive rats |
| title_sort | effect of allisartan on blood pressure and left ventricular hypertrophy through kv1 5 channels in hypertensive rats |
| topic | renal artery stenosis hypertension potassium channel left ventricular hypertrophy hypertension allisartan |
| url | http://dx.doi.org/10.1080/10641963.2021.2018597 |
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