The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury
Although the precise mechanisms contributing to secondary brain injury following traumatic brain injury are complex and obscure, a number of studies have demonstrated that inflammatory responses are an obvious and early feature in the pathogenesis of traumatic brain injury. Inflammasomes are multipr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=1;spage=49;epage=57;aulast=Ismael |
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| author | Saifudeen Ismael Heba A Ahmed Tusita Adris Kehkashan Parveen Parth Thakor Tauheed Ishrat |
| author_facet | Saifudeen Ismael Heba A Ahmed Tusita Adris Kehkashan Parveen Parth Thakor Tauheed Ishrat |
| author_sort | Saifudeen Ismael |
| collection | DOAJ |
| description | Although the precise mechanisms contributing to secondary brain injury following traumatic brain injury are complex and obscure, a number of studies have demonstrated that inflammatory responses are an obvious and early feature in the pathogenesis of traumatic brain injury. Inflammasomes are multiprotein complexes that prompt the stimulation of caspase-1 and subsequently induce the maturation and secretion of proinflammatory cytokines, such as interleukin-1β and interleukin-18. These cytokines play a pivotal role in facilitating innate immune responses and inflammation. Among various inflammasome complexes, the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is the best characterized, a crucial role for NLRP3 has been demonstrated in various brain diseases, including traumatic brain injury. Several recent studies have revealed the contribution of NLRP3 inflammasome in identifying cellular damage and stimulating inflammatory responses to aseptic tissue injury after traumatic brain injury. Even more important, blocking or inhibiting the activation of the NLRP3 inflammasome may have substantial potential to salvage tissue damage during traumatic brain injury. In this review, we summarize recently described mechanisms that are involved in the activation and regulation of the NLRP3 inflammasome. Moreover, we review the recent investigations on the contribution of the NLRP3 inflammasome in the pathophysiology of TBI, and current advances and challenges in potential NLRP3-targeted therapies. A significant contribution of NLRP3 inflammasome activation to traumatic brain injury implies that therapeutic approaches focused on targeting specific inflammasome components could significantly improve the traumatic brain injury outcomes. |
| first_indexed | 2024-12-11T00:24:22Z |
| format | Article |
| id | doaj.art-a73ceaa21d4a4335b723ab15c57b42eb |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-11T00:24:22Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-a73ceaa21d4a4335b723ab15c57b42eb2022-12-22T01:27:37ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742021-01-01161495710.4103/1673-5374.286951The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injurySaifudeen IsmaelHeba A AhmedTusita AdrisKehkashan ParveenParth ThakorTauheed IshratAlthough the precise mechanisms contributing to secondary brain injury following traumatic brain injury are complex and obscure, a number of studies have demonstrated that inflammatory responses are an obvious and early feature in the pathogenesis of traumatic brain injury. Inflammasomes are multiprotein complexes that prompt the stimulation of caspase-1 and subsequently induce the maturation and secretion of proinflammatory cytokines, such as interleukin-1β and interleukin-18. These cytokines play a pivotal role in facilitating innate immune responses and inflammation. Among various inflammasome complexes, the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is the best characterized, a crucial role for NLRP3 has been demonstrated in various brain diseases, including traumatic brain injury. Several recent studies have revealed the contribution of NLRP3 inflammasome in identifying cellular damage and stimulating inflammatory responses to aseptic tissue injury after traumatic brain injury. Even more important, blocking or inhibiting the activation of the NLRP3 inflammasome may have substantial potential to salvage tissue damage during traumatic brain injury. In this review, we summarize recently described mechanisms that are involved in the activation and regulation of the NLRP3 inflammasome. Moreover, we review the recent investigations on the contribution of the NLRP3 inflammasome in the pathophysiology of TBI, and current advances and challenges in potential NLRP3-targeted therapies. A significant contribution of NLRP3 inflammasome activation to traumatic brain injury implies that therapeutic approaches focused on targeting specific inflammasome components could significantly improve the traumatic brain injury outcomes.http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=1;spage=49;epage=57;aulast=Ismaelinflammation; interleukin-1β; nlrp3-inflammasome; caspase-1; mcc950; traumatic brain injury |
| spellingShingle | Saifudeen Ismael Heba A Ahmed Tusita Adris Kehkashan Parveen Parth Thakor Tauheed Ishrat The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury Neural Regeneration Research inflammation; interleukin-1β; nlrp3-inflammasome; caspase-1; mcc950; traumatic brain injury |
| title | The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury |
| title_full | The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury |
| title_fullStr | The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury |
| title_full_unstemmed | The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury |
| title_short | The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury |
| title_sort | nlrp3 inflammasome a potential therapeutic target for traumatic brain injury |
| topic | inflammation; interleukin-1β; nlrp3-inflammasome; caspase-1; mcc950; traumatic brain injury |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=1;spage=49;epage=57;aulast=Ismael |
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