A pan-cancer analysis reveals role of clusterin (CLU) in carcinogenesis and prognosis of human tumors
Clusterin (CLU) is a chaperone-like protein that has been demonstrated to have a direct relationship with cancer occurrence, progression, or metastasis. Clusterin was downregulated in tumor tissues using three datasets of tongue squamous carcinoma from the Gene Expression Omnibus. We further retriev...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.1056184/full |
| _version_ | 1797961797537366016 |
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| author | Yizhe Fu Yizhe Fu Qiao Du Tiehan Cui Yuying Lu Yuying Lu Guangliang Niu Guangliang Niu |
| author_facet | Yizhe Fu Yizhe Fu Qiao Du Tiehan Cui Yuying Lu Yuying Lu Guangliang Niu Guangliang Niu |
| author_sort | Yizhe Fu |
| collection | DOAJ |
| description | Clusterin (CLU) is a chaperone-like protein that has been demonstrated to have a direct relationship with cancer occurrence, progression, or metastasis. Clusterin was downregulated in tumor tissues using three datasets of tongue squamous carcinoma from the Gene Expression Omnibus. We further retrieved datasets from The Cancer Genome Atlas and Gene Expression Omnibus to thoroughly investigate the carcinogenic consequences of Clusterin. Our findings revealed that decreased Clusterin expression in malignancies was associated with a worse overall survival prognosis in individuals with multiple tumors; Clusterin gene deep deletions were found in almost all malignancies and were connected to most cancer patient’s prognosis, Clusterin DNA methylation level was dependent on tumor type, Clusterin expression was also linked to the invasion of cancer-associated CD8+ T-cells and fibroblasts in numerous cancer forms. Moreover, pathway enrichment analysis revealed that Clusterin primarily regulates biological processes such as cholesterol metabolism, phospholipid binding, and protein-lipid complex formation. Overall, our pan-cancer research suggests that Clusterin expression levels are linked to tumor carcinogenesis and prognosis, which contributes to understanding the probable mechanism of Clusterin in tumorigenesis as well as its clinical prognostic significance. |
| first_indexed | 2024-04-11T01:03:22Z |
| format | Article |
| id | doaj.art-a73e2780d1d241bdbe316740b67af30b |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-11T01:03:22Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-a73e2780d1d241bdbe316740b67af30b2023-01-04T14:53:11ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-01-011310.3389/fgene.2022.10561841056184A pan-cancer analysis reveals role of clusterin (CLU) in carcinogenesis and prognosis of human tumorsYizhe Fu0Yizhe Fu1Qiao Du2Tiehan Cui3Yuying Lu4Yuying Lu5Guangliang Niu6Guangliang Niu7Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Stomatology, Beijing Integrated Traditional Chinese and Western Medicine Hospital, Beijing, ChinaDepartment of Stomatology, Beijing Integrated Traditional Chinese and Western Medicine Hospital, Beijing, ChinaDepartment of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Stomatology, Beijing Integrated Traditional Chinese and Western Medicine Hospital, Beijing, ChinaDepartment of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Stomatology, Beijing Integrated Traditional Chinese and Western Medicine Hospital, Beijing, ChinaClusterin (CLU) is a chaperone-like protein that has been demonstrated to have a direct relationship with cancer occurrence, progression, or metastasis. Clusterin was downregulated in tumor tissues using three datasets of tongue squamous carcinoma from the Gene Expression Omnibus. We further retrieved datasets from The Cancer Genome Atlas and Gene Expression Omnibus to thoroughly investigate the carcinogenic consequences of Clusterin. Our findings revealed that decreased Clusterin expression in malignancies was associated with a worse overall survival prognosis in individuals with multiple tumors; Clusterin gene deep deletions were found in almost all malignancies and were connected to most cancer patient’s prognosis, Clusterin DNA methylation level was dependent on tumor type, Clusterin expression was also linked to the invasion of cancer-associated CD8+ T-cells and fibroblasts in numerous cancer forms. Moreover, pathway enrichment analysis revealed that Clusterin primarily regulates biological processes such as cholesterol metabolism, phospholipid binding, and protein-lipid complex formation. Overall, our pan-cancer research suggests that Clusterin expression levels are linked to tumor carcinogenesis and prognosis, which contributes to understanding the probable mechanism of Clusterin in tumorigenesis as well as its clinical prognostic significance.https://www.frontiersin.org/articles/10.3389/fgene.2022.1056184/fullclusterintongue squamous cell carcinomapan-cancer analysisprognosisimmune checkpoints |
| spellingShingle | Yizhe Fu Yizhe Fu Qiao Du Tiehan Cui Yuying Lu Yuying Lu Guangliang Niu Guangliang Niu A pan-cancer analysis reveals role of clusterin (CLU) in carcinogenesis and prognosis of human tumors Frontiers in Genetics clusterin tongue squamous cell carcinoma pan-cancer analysis prognosis immune checkpoints |
| title | A pan-cancer analysis reveals role of clusterin (CLU) in carcinogenesis and prognosis of human tumors |
| title_full | A pan-cancer analysis reveals role of clusterin (CLU) in carcinogenesis and prognosis of human tumors |
| title_fullStr | A pan-cancer analysis reveals role of clusterin (CLU) in carcinogenesis and prognosis of human tumors |
| title_full_unstemmed | A pan-cancer analysis reveals role of clusterin (CLU) in carcinogenesis and prognosis of human tumors |
| title_short | A pan-cancer analysis reveals role of clusterin (CLU) in carcinogenesis and prognosis of human tumors |
| title_sort | pan cancer analysis reveals role of clusterin clu in carcinogenesis and prognosis of human tumors |
| topic | clusterin tongue squamous cell carcinoma pan-cancer analysis prognosis immune checkpoints |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.1056184/full |
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