Incidence and Severity of SARS-CoV-2 Infections in People With Primary Ciliary Dyskinesia
Objectives: There is little data on SARS-CoV-2 in people with rare chronic diseases. We studied incidence and severity of SARS-CoV-2 and its risk factors in people with primary ciliary dyskinesia (PCD) from May 2020 to May 2022.Methods: We used self-reported questionnaire data from the COVID-PCD stu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | International Journal of Public Health |
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| Online Access: | https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605561/full |
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| author | Eva S. L. Pedersen Leonie D. Schreck Leonie D. Schreck Myrofora Goutaki Myrofora Goutaki Sara Bellu Fiona Copeland Jane S. Lucas Jane S. Lucas Marcel Zwahlen Claudia E. Kuehni Claudia E. Kuehni |
| author_facet | Eva S. L. Pedersen Leonie D. Schreck Leonie D. Schreck Myrofora Goutaki Myrofora Goutaki Sara Bellu Fiona Copeland Jane S. Lucas Jane S. Lucas Marcel Zwahlen Claudia E. Kuehni Claudia E. Kuehni |
| author_sort | Eva S. L. Pedersen |
| collection | DOAJ |
| description | Objectives: There is little data on SARS-CoV-2 in people with rare chronic diseases. We studied incidence and severity of SARS-CoV-2 and its risk factors in people with primary ciliary dyskinesia (PCD) from May 2020 to May 2022.Methods: We used self-reported questionnaire data from the COVID-PCD study at baseline or during weekly follow-ups. We studied factors associated with SARS-CoV-2 and symptoms using Poisson regression.Results: By May 2022, 728 people participated (40% male, median age 27 years; range 0–85). 87 (12%) reported SARS-CoV-2 at baseline or during follow-up and 62 people reported an incident SARS-CoV-2 infection during 716 person-years (incidence rate 9 per 100 person years). The strongest predictors for reporting SARS-CoV-2 were exposure during periods where Delta variant was dominant (IRR 4.52, 95% CI 1.92–10.6) and Omicron variants (IRR 13.3, 95% CI 5.2–33.8). Severity was mild; 12 (14%) were asymptomatic and 75 (86%) had symptoms among whom four were hospitalized. None needed intensive care and nobody died.Conclusion: The COVID-PCD study participants did not have a higher incidence of SARS-CoV-2 infections nor higher risk of severe COVID-19 disease than people from the general population. |
| first_indexed | 2024-03-12T14:30:33Z |
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| id | doaj.art-a741b76d83294a348d8d195eee4445ac |
| institution | Directory Open Access Journal |
| issn | 1661-8564 |
| language | English |
| last_indexed | 2024-03-12T14:30:33Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | International Journal of Public Health |
| spelling | doaj.art-a741b76d83294a348d8d195eee4445ac2023-08-17T13:08:45ZengFrontiers Media S.A.International Journal of Public Health1661-85642023-08-016810.3389/ijph.2023.16055611605561Incidence and Severity of SARS-CoV-2 Infections in People With Primary Ciliary DyskinesiaEva S. L. Pedersen0Leonie D. Schreck1Leonie D. Schreck2Myrofora Goutaki3Myrofora Goutaki4Sara Bellu5Fiona Copeland6Jane S. Lucas7Jane S. Lucas8Marcel Zwahlen9Claudia E. Kuehni10Claudia E. Kuehni11Institute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandInstitute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandGraduate School for Health Sciences, University of Bern, Bern, SwitzerlandInstitute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandPaediatric Respiratory Medicine, Children’s University Hospital of Bern, University of Bern, Bern, SwitzerlandAssociazione Italiana Discinesia Ciliare Primaria Sindrome di Kartagener Onlus, Onlus, ItalyPCD Support UK, London, United KingdomPrimary Ciliary Dyskinesia Centre, NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United KingdomSchool of Clinical and Experimental Medicine, Faculty of Medicine, University of Southampton, Southampton, United KingdomInstitute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandInstitute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandPaediatric Respiratory Medicine, Children’s University Hospital of Bern, University of Bern, Bern, SwitzerlandObjectives: There is little data on SARS-CoV-2 in people with rare chronic diseases. We studied incidence and severity of SARS-CoV-2 and its risk factors in people with primary ciliary dyskinesia (PCD) from May 2020 to May 2022.Methods: We used self-reported questionnaire data from the COVID-PCD study at baseline or during weekly follow-ups. We studied factors associated with SARS-CoV-2 and symptoms using Poisson regression.Results: By May 2022, 728 people participated (40% male, median age 27 years; range 0–85). 87 (12%) reported SARS-CoV-2 at baseline or during follow-up and 62 people reported an incident SARS-CoV-2 infection during 716 person-years (incidence rate 9 per 100 person years). The strongest predictors for reporting SARS-CoV-2 were exposure during periods where Delta variant was dominant (IRR 4.52, 95% CI 1.92–10.6) and Omicron variants (IRR 13.3, 95% CI 5.2–33.8). Severity was mild; 12 (14%) were asymptomatic and 75 (86%) had symptoms among whom four were hospitalized. None needed intensive care and nobody died.Conclusion: The COVID-PCD study participants did not have a higher incidence of SARS-CoV-2 infections nor higher risk of severe COVID-19 disease than people from the general population.https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605561/fullpandemicchronic lung diseaserare diseaseincidencelongitudinal |
| spellingShingle | Eva S. L. Pedersen Leonie D. Schreck Leonie D. Schreck Myrofora Goutaki Myrofora Goutaki Sara Bellu Fiona Copeland Jane S. Lucas Jane S. Lucas Marcel Zwahlen Claudia E. Kuehni Claudia E. Kuehni Incidence and Severity of SARS-CoV-2 Infections in People With Primary Ciliary Dyskinesia International Journal of Public Health pandemic chronic lung disease rare disease incidence longitudinal |
| title | Incidence and Severity of SARS-CoV-2 Infections in People With Primary Ciliary Dyskinesia |
| title_full | Incidence and Severity of SARS-CoV-2 Infections in People With Primary Ciliary Dyskinesia |
| title_fullStr | Incidence and Severity of SARS-CoV-2 Infections in People With Primary Ciliary Dyskinesia |
| title_full_unstemmed | Incidence and Severity of SARS-CoV-2 Infections in People With Primary Ciliary Dyskinesia |
| title_short | Incidence and Severity of SARS-CoV-2 Infections in People With Primary Ciliary Dyskinesia |
| title_sort | incidence and severity of sars cov 2 infections in people with primary ciliary dyskinesia |
| topic | pandemic chronic lung disease rare disease incidence longitudinal |
| url | https://www.ssph-journal.org/articles/10.3389/ijph.2023.1605561/full |
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