Physico-Chemical, Mechanical, and Biological Properties of Polylactide/<i>Portulaca oleracea</i> Extract Electrospun Fibers
Electrospinning was used to create fibrous polylactide (PLA) materials loaded with <i>Portulaca oleracea</i> (<i>P. oleracea)</i> plant extract obtained by supercritical carbon dioxide. Morphological, physico-chemical, mechanical, and biological characteristics of the fibers...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/13/3/298 |
| _version_ | 1797610225217306624 |
|---|---|
| author | Nikoleta Stoyanova Mariya Spasova Nevena Manolova Iliya Rashkov Sabina Taneva Svetlana Momchilova Ani Georgieva |
| author_facet | Nikoleta Stoyanova Mariya Spasova Nevena Manolova Iliya Rashkov Sabina Taneva Svetlana Momchilova Ani Georgieva |
| author_sort | Nikoleta Stoyanova |
| collection | DOAJ |
| description | Electrospinning was used to create fibrous polylactide (PLA) materials loaded with <i>Portulaca oleracea</i> (<i>P. oleracea)</i> plant extract obtained by supercritical carbon dioxide. Morphological, physico-chemical, mechanical, and biological characteristics of the fibers were studied. According to the SEM results, the diameters of smooth and defect-free fibers fabricated by a one-pot electrospinning method were at micron scale. All the obtained materials possess good mechanical properties. Additionally, it was found that the composite fibers exhibited considerable antioxidant activity. The antimicrobial activity of the fibrous materials against Gram-positive and Gram-negative bacteria was determined as well. In vitro studies showed that the electrospun biomaterials had no cytotoxic effects and that the combination of PLA and the <i>P. oleracea</i> extract in the fiber structure promoted cell survival and proliferation of normal mouse fibroblasts. The obtained results reveal that microfibrous mats containing the polyester—PLA and the plant extract—<i>P. oleracea</i> can be suitable for applications in wound healing. |
| first_indexed | 2024-03-11T06:12:33Z |
| format | Article |
| id | doaj.art-a741d2310d03421c9ceb145b11bb29cb |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-11T06:12:33Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-a741d2310d03421c9ceb145b11bb29cb2023-11-17T12:34:36ZengMDPI AGMembranes2077-03752023-03-0113329810.3390/membranes13030298Physico-Chemical, Mechanical, and Biological Properties of Polylactide/<i>Portulaca oleracea</i> Extract Electrospun FibersNikoleta Stoyanova0Mariya Spasova1Nevena Manolova2Iliya Rashkov3Sabina Taneva4Svetlana Momchilova5Ani Georgieva6Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 103, BG-1113 Sofia, BulgariaLaboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 103, BG-1113 Sofia, BulgariaLaboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 103, BG-1113 Sofia, BulgariaLaboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 103, BG-1113 Sofia, BulgariaDepartment of Lipid Chemistry, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 9, BG-1113 Sofia, BulgariaDepartment of Lipid Chemistry, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 9, BG-1113 Sofia, BulgariaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, bl. 25, BG-1113 Sofia, BulgariaElectrospinning was used to create fibrous polylactide (PLA) materials loaded with <i>Portulaca oleracea</i> (<i>P. oleracea)</i> plant extract obtained by supercritical carbon dioxide. Morphological, physico-chemical, mechanical, and biological characteristics of the fibers were studied. According to the SEM results, the diameters of smooth and defect-free fibers fabricated by a one-pot electrospinning method were at micron scale. All the obtained materials possess good mechanical properties. Additionally, it was found that the composite fibers exhibited considerable antioxidant activity. The antimicrobial activity of the fibrous materials against Gram-positive and Gram-negative bacteria was determined as well. In vitro studies showed that the electrospun biomaterials had no cytotoxic effects and that the combination of PLA and the <i>P. oleracea</i> extract in the fiber structure promoted cell survival and proliferation of normal mouse fibroblasts. The obtained results reveal that microfibrous mats containing the polyester—PLA and the plant extract—<i>P. oleracea</i> can be suitable for applications in wound healing.https://www.mdpi.com/2077-0375/13/3/298plant extract<i>Portulaca oleracea</i>polyesterelectrospinningnormal fibroblastswound healing |
| spellingShingle | Nikoleta Stoyanova Mariya Spasova Nevena Manolova Iliya Rashkov Sabina Taneva Svetlana Momchilova Ani Georgieva Physico-Chemical, Mechanical, and Biological Properties of Polylactide/<i>Portulaca oleracea</i> Extract Electrospun Fibers Membranes plant extract <i>Portulaca oleracea</i> polyester electrospinning normal fibroblasts wound healing |
| title | Physico-Chemical, Mechanical, and Biological Properties of Polylactide/<i>Portulaca oleracea</i> Extract Electrospun Fibers |
| title_full | Physico-Chemical, Mechanical, and Biological Properties of Polylactide/<i>Portulaca oleracea</i> Extract Electrospun Fibers |
| title_fullStr | Physico-Chemical, Mechanical, and Biological Properties of Polylactide/<i>Portulaca oleracea</i> Extract Electrospun Fibers |
| title_full_unstemmed | Physico-Chemical, Mechanical, and Biological Properties of Polylactide/<i>Portulaca oleracea</i> Extract Electrospun Fibers |
| title_short | Physico-Chemical, Mechanical, and Biological Properties of Polylactide/<i>Portulaca oleracea</i> Extract Electrospun Fibers |
| title_sort | physico chemical mechanical and biological properties of polylactide i portulaca oleracea i extract electrospun fibers |
| topic | plant extract <i>Portulaca oleracea</i> polyester electrospinning normal fibroblasts wound healing |
| url | https://www.mdpi.com/2077-0375/13/3/298 |
| work_keys_str_mv | AT nikoletastoyanova physicochemicalmechanicalandbiologicalpropertiesofpolylactideiportulacaoleraceaiextractelectrospunfibers AT mariyaspasova physicochemicalmechanicalandbiologicalpropertiesofpolylactideiportulacaoleraceaiextractelectrospunfibers AT nevenamanolova physicochemicalmechanicalandbiologicalpropertiesofpolylactideiportulacaoleraceaiextractelectrospunfibers AT iliyarashkov physicochemicalmechanicalandbiologicalpropertiesofpolylactideiportulacaoleraceaiextractelectrospunfibers AT sabinataneva physicochemicalmechanicalandbiologicalpropertiesofpolylactideiportulacaoleraceaiextractelectrospunfibers AT svetlanamomchilova physicochemicalmechanicalandbiologicalpropertiesofpolylactideiportulacaoleraceaiextractelectrospunfibers AT anigeorgieva physicochemicalmechanicalandbiologicalpropertiesofpolylactideiportulacaoleraceaiextractelectrospunfibers |