COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated disease COVID-19. Clinicians are continuously facing huge problems in the treatment of patients, as COVID-19-specific drugs are not available, hence the principle of drug repurposing serves as a one-and-only hope. Gl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-07-01
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| Series: | Genes and Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304223000211 |
| _version_ | 1797802190743535616 |
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| author | Sunny Kumar Malini Basu Pratyasha Ghosh Uttam Pal Mrinal K. Ghosh |
| author_facet | Sunny Kumar Malini Basu Pratyasha Ghosh Uttam Pal Mrinal K. Ghosh |
| author_sort | Sunny Kumar |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated disease COVID-19. Clinicians are continuously facing huge problems in the treatment of patients, as COVID-19-specific drugs are not available, hence the principle of drug repurposing serves as a one-and-only hope. Globally, the repurposing of many drugs is underway; few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical trials. Here in this review, our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs, the potential mechanism of actions, and the current clinical trial status of various drugs which are under repurposing since early 2020. At last, we briefly proposed the probable pharmacological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines. |
| first_indexed | 2024-03-13T05:01:59Z |
| format | Article |
| id | doaj.art-a7420097d246456eab543b43217aa5c0 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-13T05:01:59Z |
| publishDate | 2023-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-a7420097d246456eab543b43217aa5c02023-06-17T05:19:07ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422023-07-0110414021428COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discoverySunny Kumar0Malini Basu1Pratyasha Ghosh2Uttam Pal3Mrinal K. Ghosh4Cancer Biology and Inflammatory Disorder Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), TRUE Campus, CN-6, Sector–V, Salt Lake, Kolkata-700091 & 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, IndiaDepartment of Microbiology, Dhruba Chand Halder College, Dakshin Barasat, West Bengal 743372, India; Corresponding author.Department of Economics, Bethune College, University of Calcutta, Kolkata 700006, IndiaCancer Biology and Inflammatory Disorder Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), TRUE Campus, CN-6, Sector–V, Salt Lake, Kolkata-700091 & 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, IndiaCancer Biology and Inflammatory Disorder Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), TRUE Campus, CN-6, Sector–V, Salt Lake, Kolkata-700091 & 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India; Corresponding author.Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated disease COVID-19. Clinicians are continuously facing huge problems in the treatment of patients, as COVID-19-specific drugs are not available, hence the principle of drug repurposing serves as a one-and-only hope. Globally, the repurposing of many drugs is underway; few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical trials. Here in this review, our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs, the potential mechanism of actions, and the current clinical trial status of various drugs which are under repurposing since early 2020. At last, we briefly proposed the probable pharmacological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines.http://www.sciencedirect.com/science/article/pii/S2352304223000211Clinical trialsCOVID-19Drug discoveryPharmacologyRepurposing of drugsSARS-CoV-2 |
| spellingShingle | Sunny Kumar Malini Basu Pratyasha Ghosh Uttam Pal Mrinal K. Ghosh COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery Genes and Diseases Clinical trials COVID-19 Drug discovery Pharmacology Repurposing of drugs SARS-CoV-2 |
| title | COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
| title_full | COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
| title_fullStr | COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
| title_full_unstemmed | COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
| title_short | COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery |
| title_sort | covid 19 therapeutics clinical application of repurposed drugs and futuristic strategies for target based drug discovery |
| topic | Clinical trials COVID-19 Drug discovery Pharmacology Repurposing of drugs SARS-CoV-2 |
| url | http://www.sciencedirect.com/science/article/pii/S2352304223000211 |
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