Translational Medicine in Uremic Vascular Calcification: Scavenging ROS Attenuates p-Cresyl Sulfate-Activated Caspase-1, NLRP3 Inflammasome and Eicosanoid Inflammation in Human Arterial Smooth Muscle Cells

Translational Medicine in Uremic Vascular Calcification: Scavenging ROS Attenuates p-Cresyl Sulfate-Activated Caspase-1, NLRP3 Inflammasome and Eicosanoid Inflammation in Human Arterial Smooth Muscle Cells

We formerly proved that uremic vascular calcification (UVC) correlates tightly with oxidative elastic lamina (EL) injury and two cell fates (apoptosis and osteocytic conversion) in smooth muscle cells (SMC) of chronic kidney disease (CKD) patients and eliminating p-cresyl sulfate (PCS)-activated int...

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Bibliographic Details
Main Authors: Jia-Feng Chang, Hsiao-Ling Kuo, Shih-Hao Liu, Chih-Yu Hsieh, Chih-Ping Hsu, Kuo-Chin Hung, Ting-Ming Wang, Chang-Chin Wu, Kuo-Cheng Lu, Wei-Ning Lin, Chi-Feng Hung, Wen-Chin Ko
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Life
Subjects:
Caspase-1
COX2
cPLA2
IL-1β
inflammasome
NLRP3
Online Access:https://www.mdpi.com/2075-1729/12/5/769

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