Connectome spectral analysis to track EEG task dynamics on a subsecond scale
We present an approach for tracking fast spatiotemporal cortical dynamics in which we combine white matter connectivity data with source-projected electroencephalographic (EEG) data. We employ the mathematical framework of graph signal processing in order to derive the Fourier modes of the brain str...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-11-01
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| Series: | NeuroImage |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811920306236 |
| _version_ | 1818609103183806464 |
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| author | Katharina Glomb Joan Rué Queralt David Pascucci Michaël Defferrard Sébastien Tourbier Margherita Carboni Maria Rubega Serge Vulliémoz Gijs Plomp Patric Hagmann |
| author_facet | Katharina Glomb Joan Rué Queralt David Pascucci Michaël Defferrard Sébastien Tourbier Margherita Carboni Maria Rubega Serge Vulliémoz Gijs Plomp Patric Hagmann |
| author_sort | Katharina Glomb |
| collection | DOAJ |
| description | We present an approach for tracking fast spatiotemporal cortical dynamics in which we combine white matter connectivity data with source-projected electroencephalographic (EEG) data. We employ the mathematical framework of graph signal processing in order to derive the Fourier modes of the brain structural connectivity graph, or “network harmonics”. These network harmonics are naturally ordered by smoothness. Smoothness in this context can be understood as the amount of variation along the cortex, leading to a multi-scale representation of brain connectivity. We demonstrate that network harmonics provide a sparse representation of the EEG signal, where, at certain times, the smoothest 15 network harmonics capture 90% of the signal power. This suggests that network harmonics are functionally meaningful, which we demonstrate by using them as a basis for the functional EEG data recorded from a face detection task. There, only 13 network harmonics are sufficient to track the large-scale cortical activity during the processing of the stimuli with a 50 ms resolution, reproducing well-known activity in the fusiform face area as well as revealing co-activation patterns in somatosensory/motor and frontal cortices that an unconstrained ROI-by-ROI analysis fails to capture. The proposed approach is simple and fast, provides a means of integration of multimodal datasets, and is tied to a theoretical framework in mathematics and physics. Thus, network harmonics point towards promising research directions both theoretically - for example in exploring the relationship between structure and function in the brain - and practically - for example for network tracking in different tasks and groups of individuals, such as patients. |
| first_indexed | 2024-12-16T14:53:13Z |
| format | Article |
| id | doaj.art-a742bda64cfb44aa9b7349eac622f363 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-16T14:53:13Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-a742bda64cfb44aa9b7349eac622f3632022-12-21T22:27:33ZengElsevierNeuroImage1095-95722020-11-01221117137Connectome spectral analysis to track EEG task dynamics on a subsecond scaleKatharina Glomb0Joan Rué Queralt1David Pascucci2Michaël Defferrard3Sébastien Tourbier4Margherita Carboni5Maria Rubega6Serge Vulliémoz7Gijs Plomp8Patric Hagmann9Connectomics Lab, Dept. of Radiology, University Hospital of Lausanne and University of Lausanne (CHUV-UNIL), Lausanne, Switzerland; Corresponding author.Connectomics Lab, Dept. of Radiology, University Hospital of Lausanne and University of Lausanne (CHUV-UNIL), Lausanne, Switzerland; Perceptual Networks Group, Dept. of Psychology, University of Fribourg, Fribourg, SwitzerlandLaboratory of Psychophysics, EPFL, Lausanne, SwitzerlandSignal Processing Lab 2, EPFL, Lausanne, SwitzerlandConnectomics Lab, Dept. of Radiology, University Hospital of Lausanne and University of Lausanne (CHUV-UNIL), Lausanne, SwitzerlandEEG and Epilepsy, Neurology, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland; Functional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, Geneva, SwitzerlandNeuromove-Rehab Lab, University of Padova, Padova, ItalyEEG and Epilepsy, Neurology, University Hospitals of Geneva and University of Geneva, Geneva, SwitzerlandPerceptual Networks Group, Dept. of Psychology, University of Fribourg, Fribourg, SwitzerlandConnectomics Lab, Dept. of Radiology, University Hospital of Lausanne and University of Lausanne (CHUV-UNIL), Lausanne, SwitzerlandWe present an approach for tracking fast spatiotemporal cortical dynamics in which we combine white matter connectivity data with source-projected electroencephalographic (EEG) data. We employ the mathematical framework of graph signal processing in order to derive the Fourier modes of the brain structural connectivity graph, or “network harmonics”. These network harmonics are naturally ordered by smoothness. Smoothness in this context can be understood as the amount of variation along the cortex, leading to a multi-scale representation of brain connectivity. We demonstrate that network harmonics provide a sparse representation of the EEG signal, where, at certain times, the smoothest 15 network harmonics capture 90% of the signal power. This suggests that network harmonics are functionally meaningful, which we demonstrate by using them as a basis for the functional EEG data recorded from a face detection task. There, only 13 network harmonics are sufficient to track the large-scale cortical activity during the processing of the stimuli with a 50 ms resolution, reproducing well-known activity in the fusiform face area as well as revealing co-activation patterns in somatosensory/motor and frontal cortices that an unconstrained ROI-by-ROI analysis fails to capture. The proposed approach is simple and fast, provides a means of integration of multimodal datasets, and is tied to a theoretical framework in mathematics and physics. Thus, network harmonics point towards promising research directions both theoretically - for example in exploring the relationship between structure and function in the brain - and practically - for example for network tracking in different tasks and groups of individuals, such as patients.http://www.sciencedirect.com/science/article/pii/S1053811920306236 |
| spellingShingle | Katharina Glomb Joan Rué Queralt David Pascucci Michaël Defferrard Sébastien Tourbier Margherita Carboni Maria Rubega Serge Vulliémoz Gijs Plomp Patric Hagmann Connectome spectral analysis to track EEG task dynamics on a subsecond scale NeuroImage |
| title | Connectome spectral analysis to track EEG task dynamics on a subsecond scale |
| title_full | Connectome spectral analysis to track EEG task dynamics on a subsecond scale |
| title_fullStr | Connectome spectral analysis to track EEG task dynamics on a subsecond scale |
| title_full_unstemmed | Connectome spectral analysis to track EEG task dynamics on a subsecond scale |
| title_short | Connectome spectral analysis to track EEG task dynamics on a subsecond scale |
| title_sort | connectome spectral analysis to track eeg task dynamics on a subsecond scale |
| url | http://www.sciencedirect.com/science/article/pii/S1053811920306236 |
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