The role of regulatory T cells in the modulation of anti-tumor immune response
It has been shown that the loss of regulatory function by deple + Regulatory T cells (Treg) represent a subset of CD4 T cells whose function is to suppress immune responses. Treg lymphocytes can be divided into two subsets: natural nTreg lymphocytes that are developed in the thymus and inducible...
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| Format: | Article |
| Language: | English |
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Serbian Medical Society
2013-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2013/0370-81791304262R.pdf |
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| author | Radosavljević Gordana D. Jovanović Ivan P. Kanjevac Tatjana V. Arsenijević Nebojša N. |
| author_facet | Radosavljević Gordana D. Jovanović Ivan P. Kanjevac Tatjana V. Arsenijević Nebojša N. |
| author_sort | Radosavljević Gordana D. |
| collection | DOAJ |
| description | It has been shown that the loss of regulatory function by deple + Regulatory T cells (Treg) represent a subset of CD4 T cells whose function is to suppress immune responses. Treg lymphocytes can be divided into two subsets: natural nTreg lymphocytes that are developed in the thymus and inducible iTreg lymphocytes, which originate from conventional T lymphocytes on the periphery. The majority of Treg lymphocytes express high levels of interleukin2 (IL2) receptor α chain (CD25) and transcription factor FoxP3 (critical for the development and suppressor activity of iTreg lymphocytes). Cancer cells can modulate antitumor immune response indirectly, through the activation of Treg lymphocytes. tion of tumorinduced Treg lymphocytes may enhance effectors response, resulting in tumor rejection, while the increased number of Treg lymphocytes effectively prevents tumor destruction. nTreg lymphocytes express increasingly CTLA4 and membrane bound TGFβ, which inhibits cytokine production and responses of effectors lymphocytes. iTreg lymphocytes secrete immunosuppressive cytokines such as IL10 and TGFβ. Treg lymphocytes represent one of important obstruction in antitumor immunity. |
| first_indexed | 2024-12-16T12:11:29Z |
| format | Article |
| id | doaj.art-a743e44a02934b0babf36acefda27283 |
| institution | Directory Open Access Journal |
| issn | 0370-8179 |
| language | English |
| last_indexed | 2024-12-16T12:11:29Z |
| publishDate | 2013-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-a743e44a02934b0babf36acefda272832022-12-21T22:32:12ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792013-01-011413-426226710.2298/SARH1304262RThe role of regulatory T cells in the modulation of anti-tumor immune responseRadosavljević Gordana D.Jovanović Ivan P.Kanjevac Tatjana V.Arsenijević Nebojša N.It has been shown that the loss of regulatory function by deple + Regulatory T cells (Treg) represent a subset of CD4 T cells whose function is to suppress immune responses. Treg lymphocytes can be divided into two subsets: natural nTreg lymphocytes that are developed in the thymus and inducible iTreg lymphocytes, which originate from conventional T lymphocytes on the periphery. The majority of Treg lymphocytes express high levels of interleukin2 (IL2) receptor α chain (CD25) and transcription factor FoxP3 (critical for the development and suppressor activity of iTreg lymphocytes). Cancer cells can modulate antitumor immune response indirectly, through the activation of Treg lymphocytes. tion of tumorinduced Treg lymphocytes may enhance effectors response, resulting in tumor rejection, while the increased number of Treg lymphocytes effectively prevents tumor destruction. nTreg lymphocytes express increasingly CTLA4 and membrane bound TGFβ, which inhibits cytokine production and responses of effectors lymphocytes. iTreg lymphocytes secrete immunosuppressive cytokines such as IL10 and TGFβ. Treg lymphocytes represent one of important obstruction in antitumor immunity.http://www.doiserbia.nb.rs/img/doi/0370-8179/2013/0370-81791304262R.pdfregulatory T cellstumorsantitumor immune response |
| spellingShingle | Radosavljević Gordana D. Jovanović Ivan P. Kanjevac Tatjana V. Arsenijević Nebojša N. The role of regulatory T cells in the modulation of anti-tumor immune response Srpski Arhiv za Celokupno Lekarstvo regulatory T cells tumors antitumor immune response |
| title | The role of regulatory T cells in the modulation of anti-tumor immune response |
| title_full | The role of regulatory T cells in the modulation of anti-tumor immune response |
| title_fullStr | The role of regulatory T cells in the modulation of anti-tumor immune response |
| title_full_unstemmed | The role of regulatory T cells in the modulation of anti-tumor immune response |
| title_short | The role of regulatory T cells in the modulation of anti-tumor immune response |
| title_sort | role of regulatory t cells in the modulation of anti tumor immune response |
| topic | regulatory T cells tumors antitumor immune response |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2013/0370-81791304262R.pdf |
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